J
Jonathan Livny
Researcher at Broad Institute
Publications - 81
Citations - 8473
Jonathan Livny is an academic researcher from Broad Institute. The author has contributed to research in topics: Gene & Transcriptome. The author has an hindex of 37, co-authored 73 publications receiving 6369 citations. Previous affiliations of Jonathan Livny include Massachusetts Institute of Technology & University of Michigan.
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Journal ArticleDOI
Nucleic acid detection with CRISPR-Cas13a/C2c2
Jonathan S. Gootenberg,Omar O. Abudayyeh,Jeong Wook Lee,Patrick Essletzbichler,Aaron J. Dy,Aaron J. Dy,Julia Joung,Vanessa Verdine,Nina M. Donghia,Nichole M. Daringer,Catherine A. Freije,Catherine A. Freije,Cameron Myhrvold,Cameron Myhrvold,Roby P. Bhattacharyya,Jonathan Livny,Aviv Regev,Aviv Regev,Eugene V. Koonin,Deborah T. Hung,Pardis C. Sabeti,James J. Collins,Feng Zhang +22 more
TL;DR: A Cas13a-based molecular detection platform, termed Specific High-Sensitivity Enzymatic Reporter UnLOCKing (SHERLOCK), is used to detect specific strains of Zika and Dengue virus, distinguish pathogenic bacteria, genotype human DNA, and identify mutations in cell-free tumor DNA.
Journal ArticleDOI
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.
Leore T. Geller,Michal Barzily-Rokni,Tal Danino,Oliver Jonas,Oliver Jonas,Noam Shental,Deborah Nejman,Nancy Gavert,Yaara Zwang,Zachary A. Cooper,Kevin Shee,Christoph A. Thaiss,Alexandre Reuben,Jonathan Livny,Roi Avraham,Dennie T. Frederick,Matteo Ligorio,Kelly Chatman,Stephen Johnston,Carrie M. Mosher,Alexander Brandis,Garold Fuks,Candice Gurbatri,Vancheswaran Gopalakrishnan,Michael P. Kim,Mark W. Hurd,Matthew H.G. Katz,Jason B. Fleming,Anirban Maitra,David Smith,Matthew Skalak,Jeffrey Bu,Monia Michaud,Sunia A. Trauger,Iris Barshack,Iris Barshack,Talia Golan,Talia Golan,Judith Sandbank,Keith T. Flaherty,Anna Mandinova,Anna Mandinova,Wendy S. Garrett,Wendy S. Garrett,Sarah P. Thayer,Cristina R. Ferrone,Curtis Huttenhower,Curtis Huttenhower,Sangeeta N. Bhatia,Dirk Gevers,Jennifer A. Wargo,Todd R. Golub,Todd R. Golub,Ravid Straussman +53 more
TL;DR: By studying colon cancer models, it is found that bacteria can metabolize the chemotherapeutic drug gemcitabine into its inactive form, 2′,2′-difluorodeoxyuridine, seen primarily in Gammaproteobacteria.
Nucleic acid detection with CRISPR-Cas13a/C2c2
Jonathan S. Gootenberg,Omar O. Abudayyeh,Jeong Wook Lee,Patrick Essletzbichler,Aaron J. Dy,Aaron J. Dy,Julia Joung,Vanessa Verdine,Nina M. Donghia,Nichole M. Daringer,Catherine A. Freije,Catherine A. Freije,Cameron Myhrvold,Cameron Myhrvold,Roby P. Bhattacharyya,Jonathan Livny,Aviv Regev,Aviv Regev,Eugene V. Koonin,Deborah T. Hung,Pardis C. Sabeti,James J. Collins,Feng Zhang +22 more
TL;DR: In this paper, a CRISPR-Dx-based molecular detection platform, termed Specific High-Sensitivity Enzymatic Reporter Unlocking (SHERLOCK), was proposed to detect specific strains of Zika and Dengue virus, distinguish pathogenic bacteria, genotype human DNA, and identify mutations in cell-free tumor DNA.
Journal ArticleDOI
Simultaneous generation of many RNA-seq libraries in a single reaction
Alexander A. Shishkin,Georgia Giannoukos,Alper Kucukural,Dawn Ciulla,Michele Busby,Christine Surka,Jenny Chen,Roby P. Bhattacharyya,Robert F. Rudy,Milesh M. Patel,Nathaniel Novod,Deborah T. Hung,Andreas Gnirke,Manuel Garber,Mitchell Guttman,Jonathan Livny +15 more
TL;DR: RNAtag-Seq, an approach to generate multiple RNA-seq libraries in a single reaction, lowers time and cost per sample, and it produces data on prokaryotic and eukaryotic samples that are comparable to those generated by traditional strand-specificRNA-seq approaches.
Journal ArticleDOI
Bacteriophage control of Shiga toxin 1 production and release by Escherichia coli
Patrick L. Wagner,Jonathan Livny,Melody N. Neely,David W. K. Acheson,David I. Friedman,Matthew K. Waldor,Matthew K. Waldor +6 more
TL;DR: It is found that replication of the phage genome, with the associated increase in stx1AB copy number, is the most quantitatively important mechanism by which H‐19B induction increases Stx1 production.