Michael Hennig

TL;DR: A detailed, molecular understanding of the regulatory role of Fc-oligosaccharide core fucosylation in improving ADCC is obtained and a unique mechanism by which the immune system can regulate antibody-mediated effector functions is suggested.

TL;DR: The target protein with an inhibitor that showed cholesterol lowering in vivo opens the way for the structure-based design of new OSC inhibitors, and the complex with the reaction product lanosterol gives a clear picture of the way in which the enzyme achieves product specificity in this highly exothermic cyclization reaction.

TL;DR: This Review provides a framework to understand this evolution of biophysical technologies by describing the key biophysical methods, the information they can provide and the ways in which they can be applied at different stages of the drug discovery process.

TL;DR: The crystal structure of the extracellular domain of human NEP complexed with the generic metalloproteinase inhibitor phosphoramidon is described and reveals two multiply connected folding domains which embrace a large central cavity containing the active site.