Showing papers by "Michael J. Caulfield published in 2000"
TL;DR: Boosting an HBs protein-primed response with the adjuvanted DNA vaccine resulted in a dramatic increase in the HBs-specific IgG2a response reflecting a shift towards a TH1 response.
84 citations
Patent•
03 Jul 2000TL;DR: In this article, an adenoviral vector is described which carries a codon-optimized gag gene, along with a heterologous promoter and transcription terminator, which can effectively prevent HIV infection when administered to humans either alone or as part of a prime and boost regime also with a vaccine plasmid.
Abstract: An adenoviral vector is described which carries a codon-optimized gag gene, along with a heterologous promoter and transcription terminator. This viral vaccine can effectively prevent HIV infection when administered to humans either alone or as part of a prime and boost regime also with a vaccine plasmid.
48 citations
TL;DR: The results indicate that the rhesus monkey model may be useful for pre-clinical evaluation of combination vaccines.
8 citations