J
Jeffrey B. Ulmer
Researcher at Novartis
Publications - 160
Citations - 15455
Jeffrey B. Ulmer is an academic researcher from Novartis. The author has contributed to research in topics: DNA vaccination & Antigen. The author has an hindex of 61, co-authored 154 publications receiving 14655 citations. Previous affiliations of Jeffrey B. Ulmer include United States Military Academy & Merck & Co..
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Journal ArticleDOI
Heterologous protection against influenza by injection of DNA encoding a viral protein
Jeffrey B. Ulmer,John J. Donnelly,Suezanne E. Parker,Gary Rhodes,Philip L. Felgner,V. J. Dwarki,Stanislaw H. Gromkowski,R. Randall Deck,Corrille M. DeWitt,Arthur Friedman,Linda A. Hawe,Karen R. Leander,Douglas Martinez,Helen C. Perry,John W. Shiver,Donna L. Montgomery,Margaret A. Liu +16 more
TL;DR: To generate a viral antigen for presentation to the immune system without the limitations of direct peptide delivery or viral vectors, plasmid DNA encoding influenza A nucleop protein was injected into the quadriceps of BALB/c mice and resulted in the generation of nucleoprotein-specific CTLs.
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Increased DNA vaccine delivery and immunogenicity by electroporation in vivo.
Georg Widera,Melissa B. Austin,Dietmar Rabussay,Cheryl Goldbeck,Susan W. Barnett,Minchao Chen,Louisa Leung,Gillis R. Otten,Thudium Kent B,Mark Selby,Jeffrey B. Ulmer +10 more
TL;DR: Electroporation is shown to substantially increase delivery of DNA to cells, resulting in increased expression and elevated immune responses, and electroporation appears to overcome this barrier to transfection in vivo.
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Immunogenicity and protective efficacy of a tuberculosis DNA vaccine
Kris Huygen,Olivier Denis,Donna L. Montgomery,Yawman Am,Deck Rr,DeWitt Cm,Ian M. Orme,Baldwin S,C.D. D'Souza,Annie Drowart,E Lozes,Paul Vandenbussche,Van Vooren Jp,Liu Margaret A,Jeffrey B. Ulmer +14 more
TL;DR: Results indicate that immunization with DNA encoding a mycobacterial antigen provides an efficient and simple method for generating protective immunity and that this technique may be useful for defining the protective antigens of M. tuberculosis, leading to the development of a more effective vaccine.
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Targeting the innate immune response with improved vaccine adjuvants
TL;DR: Rational approaches to the discovery and development of immunostimulatory compounds and vaccine formulations that target innate immune responses are considered.
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Preclinical efficacy of a prototype DNA vaccine: Enhanced protection against antigenic drift in influenza virus
John J. Donnelly,Arthur Friedman,Douglas Martinez,Donna L. Montgomery,John W. Shiver,Sherri L. Motzel,Jeffrey B. Ulmer,Margaret A. Liu +7 more
TL;DR: It is demonstrated that DNA vaccines may be more effective, particularly against different strains of virus, than inactivated virus or subvirion vaccines.