M
Michael J. Garlepp
Researcher at Curtin University
Publications - 57
Citations - 2293
Michael J. Garlepp is an academic researcher from Curtin University. The author has contributed to research in topics: Inclusion body myositis & Human leukocyte antigen. The author has an hindex of 24, co-authored 57 publications receiving 2217 citations. Previous affiliations of Michael J. Garlepp include University of Western Australia & Royal Perth Hospital.
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Journal ArticleDOI
The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases
Patricia Price,Campbell S. Witt,Richard J.N. Allcock,David Sayer,Michael J. Garlepp,C.C. Kok,Martyn A. French,Simon Mallal,Frank T. Christiansen +8 more
TL;DR: Several candidate genes in the central MHC have the potential to modulate immune or inflammatory responses in an antigen‐independent manner, as is seen in studies of cultured cells from healthy carriers of the 8.1 AH.
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Inflammatory myopathies: Clinical, diagnostic and therapeutic aspects
TL;DR: Improved understanding of the molecular mechanisms of muscle injury in the inflammatory myopathies should lead to the development of more specific forms of immunotherapy for these conditions.
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Establishment of a murine model of malignant mesothelioma.
TL;DR: An asbestos‐induced murine model of MM was developed both as an in vivo‐passaged malignancy and as in vitro‐established cell lines, which would be invaluable for use in the study of various cellular, molecular and genetic aspects of the disease.
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Establishment and characterization of five human malignant mesothelioma cell lines derived from pleural effusions
L. S. Manning,Darrel Whitaker,Ashleigh R. Murch,Michael J. Garlepp,Mark R. Davis,Arthur W. Musk,Bruce W. S. Robinson +6 more
TL;DR: The establishment of 5 human MM cell lines were established from pleural effusions of patients with known crocidolite asbestos exposure, providing an opportunity for comparative study of several aspects of the biology of MM in vitro as well as screening new treatment modalities.
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HLA associations with inclusion body myositis
TL;DR: The phenotype and phenotype data provide support for an autoimmune etiology for, and genetic predisposition to, IBM.