M
Michael M. Magee
Researcher at Merck & Co.
Publications - 1
Citations - 95
Michael M. Magee is an academic researcher from Merck & Co.. The author has contributed to research in topics: hERG & Genetic model. The author has an hindex of 1, co-authored 1 publications receiving 92 citations.
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Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
Zhi-Qiang Yang,James C. Barrow,William D. Shipe,Kelly-Ann S. Schlegel,Youheng Shu,F. Vivien Yang,Craig W. Lindsley,Craig W. Lindsley,Kenneth E. Rittle,Mark G. Bock,Mark G. Bock,George D. Hartman,Victor N. Uebele,Cindy E. Nuss,Steven V. Fox,Richard L. Kraus,Scott M. Doran,Thomas M. Connolly,Cuyue Tang,Jeanine E. Ballard,Yuhsin Kuo,Emily D. Adarayan,Thomayant Prueksaritanont,Matthew M. Zrada,Michael J. Marino,Michael J. Marino,Valerie Kuzmick Graufelds,Anthony G. DiLella,Ian J. Reynolds,Hugo M. Vargas,Hugo M. Vargas,Patricia B. Bunting,Richard Woltmann,Michael M. Magee,Kenneth S. Koblan,John J. Renger +35 more
TL;DR: Compound 30 demonstrated a robust reduction in the number and duration of seizures at 33 nM plasma concentration, with no cardiovascular effects at up to 5.6 microM, and is a useful tool for probing the effects of T-type calcium channel inhibition.