Z
Zhi-Qiang Yang
Researcher at United States Military Academy
Publications - 8
Citations - 206
Zhi-Qiang Yang is an academic researcher from United States Military Academy. The author has contributed to research in topics: T-type calcium channel & Allosteric regulation. The author has an hindex of 5, co-authored 7 publications receiving 198 citations. Previous affiliations of Zhi-Qiang Yang include Merck & Co..
Papers
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Journal ArticleDOI
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
Zhi-Qiang Yang,James C. Barrow,William D. Shipe,Kelly-Ann S. Schlegel,Youheng Shu,F. Vivien Yang,Craig W. Lindsley,Craig W. Lindsley,Kenneth E. Rittle,Mark G. Bock,Mark G. Bock,George D. Hartman,Victor N. Uebele,Cindy E. Nuss,Steven V. Fox,Richard L. Kraus,Scott M. Doran,Thomas M. Connolly,Cuyue Tang,Jeanine E. Ballard,Yuhsin Kuo,Emily D. Adarayan,Thomayant Prueksaritanont,Matthew M. Zrada,Michael J. Marino,Michael J. Marino,Valerie Kuzmick Graufelds,Anthony G. DiLella,Ian J. Reynolds,Hugo M. Vargas,Hugo M. Vargas,Patricia B. Bunting,Richard Woltmann,Michael M. Magee,Kenneth S. Koblan,John J. Renger +35 more
TL;DR: Compound 30 demonstrated a robust reduction in the number and duration of seizures at 33 nM plasma concentration, with no cardiovascular effects at up to 5.6 microM, and is a useful tool for probing the effects of T-type calcium channel inhibition.
Journal ArticleDOI
Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists
Victor N. Uebele,Cindy E. Nuss,Steven V. Fox,Susan L. Garson,Razvan Cristescu,Scott M. Doran,Richard L. Kraus,Vincent P. Santarelli,Yuxing Li,Æ James C. Barrow,Zhi-Qiang Yang,Kelly-Ann S. Schlegel,Kenneth E. Rittle,Thomas S. Reger,Rodney A. Bednar,Wei Lemaire,Faith A. Mullen,Jeanine E. Ballard,Cuyue Tang,Ge Dai,Owen B. McManus,Kenneth S. Koblan,John J. Renger +22 more
TL;DR: The development of a T-type calcium channel radioligand has been used to demonstrate structurally distinct TTAs interact at allosteric sites and to confirm the potential for synergistic inhibition of T- type calcium channels with structurally diverse antagonists.
Journal ArticleDOI
Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators.
Zhi-Qiang Yang,Shu Youheng,Lei Ma,Marion Wittmann,William J. Ray,Matthew A. Seager,Kenneth A. Koeplinger,Charles D. Thompson,George D. Hartman,Mark T. Bilodeau,Scott D. Kuduk +10 more
TL;DR: A series of naphthyl-fused 5-membered lactams were identified as a new class of M1 positive allosteric modulators and were found to possess good potency and in vivo efficacy.
Patent
Heterocycle phenyl amide t-type calcium channel antagonists
James C. Barrow,Paul J. Coleman,Thomas S. Reger,Kelly-Ann S. Schlegel,Shu Youheng,Zhi-Qiang Yang +5 more
TL;DR: In this paper, the authors present a list of heterocycle phenyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T type calcium channels are involved.
Patent
Isoindolone m1 receptor positive allosteric modulators
TL;DR: In this paper, the M1 receptor positive allosteric modulators are used in the treatment of diseases in which the M 1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders.