M
Michael Meldgaard
Researcher at University of Southern Denmark
Publications - 17
Citations - 1016
Michael Meldgaard is an academic researcher from University of Southern Denmark. The author has contributed to research in topics: Furanose & Tumor necrosis factor alpha. The author has an hindex of 13, co-authored 17 publications receiving 942 citations. Previous affiliations of Michael Meldgaard include University of Copenhagen.
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Journal ArticleDOI
Microglia protect neurons against ischemia by synthesis of tumor necrosis factor.
Kate Lykke Lambertsen,Bettina Hjelm Clausen,Alicia A. Babcock,Rikke Gregersen,Christina Fenger,Helle Hvilsted Nielsen,Laila Skov Haugaard,Martin Wirenfeldt,Marianne Nielsen,Frederik Dagnæs-Hansen,Horst Bluethmann,Nils J. Færgeman,Michael Meldgaard,Tomas Deierborg,Bente Finsen +14 more
TL;DR: It is reported that TNF deficiency is associated with reduced microglial population size and Toll-like receptor 2 expression in unmanipulated brain, which might also influence the neuronal response to injury.
Journal ArticleDOI
A quantitative study of microglial-macrophage synthesis of tumor necrosis factor during acute and late focal cerebral ischemia in mice.
TL;DR: The data suggest that the pathophysiologically important TNF, produced in the acute phase from mins to 6 hours after an ischemic attack in mice, is synthesized by microglia-macrophages.
Journal ArticleDOI
Changes in brain levels of N‐acylethanolamines and 2‐arachidonoylglycerol in focal cerebral ischemia in mice
Matilda Degn,Kate Lykke Lambertsen,Gitte Lindved Petersen,Michael Meldgaard,Andreas Artmann,Bettina Hjelm Clausen,Steen Honoré Hansen,Bente Finsen,Harald S. Hansen,Trine Meldgaard Lund +9 more
TL;DR: The results suggest that NAEs and 2‐AG may be involved in regulation of neuroprotection during focal cerebral ischemia in mice.
Journal ArticleDOI
Population control of resident and immigrant microglia by mitosis and apoptosis
Martin Wirenfeldt,Lasse Dissing-Olesen,Alicia A. Babcock,Marianne Nielsen,Michael Meldgaard,Jens Zimmer,Iñigo Azcoitia,Robert Graham Quinton Leslie,Frederik Dagnæs-Hansen,Bente Finsen +9 more
TL;DR: Understanding of the microglial response to neural damage is broadened by demonstrating that simultaneously occurring mitosis and apoptosis regulate expansion and reduction of both resident and immigrant microglia cell populations.
Journal ArticleDOI
A Role for Interferon-gamma in Focal Cerebral Ischemia in Mice
Kate Lykke Lambertsen,Rikke Gregersen,Michael Meldgaard,Bettina Hjelm Clausen,Eva Kildall Heibøl,Rune Ladeby,Jens Knudsen,Aase Frandsen,Trevor Owens,Bente Finsen +9 more
TL;DR: The data argues against a role for IFNγ in cerebral ischemia under normal conditions, however, when present,IFNγ significantly exacerbates ischemIA-induced brain damage by mechanisms that appear to be independent of TNF or synergistic neurotoxic interactions of IFnγ and TNF.