M
Michael O’Connell
Researcher at University of Pittsburgh
Publications - 53
Citations - 4781
Michael O’Connell is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Colorectal cancer & Oxaliplatin. The author has an hindex of 24, co-authored 53 publications receiving 4317 citations. Previous affiliations of Michael O’Connell include University of Rochester.
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Journal ArticleDOI
The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population
Jessica LaRusch,Antonio Lozano-Leon,Kimberly Stello,Amanda Moore,Venkata Muddana,Michael O’Connell,Brenda Diergaarde,Dhiraj Yadav,David C. Whitcomb +8 more
TL;DR: The common CTRC variant c.180T acts as disease modifier that promotes progression from RAP to CP, especially in patients with CFTR or SPINK1 variants, alcohol, or smoking, suggesting that smoking rather than alcohol may be the driving factor in this association.
Journal ArticleDOI
FOLFOX and FLOX regimens for the adjuvant treatment of resected stage II and III colon cancer.
TL;DR: The efficacy and toxicities of the two regimens used in the treatment of stage II/III colon cancer are reviewed and are meant to serve as a guide for clinical practice.
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Smoking is underrecognized as a risk factor for chronic pancreatitis.
Dhiraj Yadav,Adam Slivka,Stuart Sherman,Robert H. Hawes,Michelle A. Anderson,Frank R. Burton,Randall E. Brand,Michele D. Lewis,Timothy B. Gardner,Andres Gelrud,James A. DiSario,Stephen T. Amann,John Baillie,Christopher Lawrence,Michael O’Connell,Albert B. Lowenfels,Peter A. Banks,David C. Whitcomb +17 more
TL;DR: Physicians often underrecognize smoking as a CP risk factor, and efforts are needed to raise awareness of the association between smoking and CP.
Journal ArticleDOI
Response to preoperative multimodality therapy predicts survival in patients with carcinoma of the rectum
Mark S. Roh,Linda H. Colangelo,S. Wieand,Michael O’Connell,N. J. Petrelli,Roy E. Smith,Eleftherios P. Mamounas,D. Hyams,Norman Wolmark +8 more
TL;DR: The NSABP R-03 trial compared preoperative neoadjuvant to postoperative adjuvant chemoradiation and the endpoints were overall (OS), disease-free (DFS) and relapse- free (RFS) survival.
Journal ArticleDOI
Use and perceived effectiveness of non‐analgesic medical therapies for chronic pancreatitis in the United States
Frank R. Burton,Samer Alkaade,Dennis Collins,Venkata Muddana,Adam Slivka,Randall E. Brand,Andres Gelrud,Peter A. Banks,Stuart Sherman,Michelle A. Anderson,Joseph Romagnuolo,Christopher Lawrence,John Baillie,Timothy B. Gardner,Michele D. Lewis,Stephen T. Amann,John G. Lieb,Michael O’Connell,Elizabeth D. Kennard,Dhiraj Yadav,David C. Whitcomb,Chris E. Forsmark +21 more
TL;DR: Aliment Pharmacol Ther 2011; 33: 149–159