Michael Oelgeschläger

TL;DR: A biological mechanism for the organization of AJs and the modulation of mechanical properties of cells is described and a new perspective on how estrogens and anti-estrogens might influence the formation of breast tumors is provided.

TL;DR: The proactive use of the likelihood of co-exposure, together with the new approach of methods-based testing, may be a timely and feasible way of identifying those substances and mixtures where hazards may have been overlooked and regulatory action is needed.

TL;DR: A bone morphogenetic protein (Bmp)-reporter ESC line, isolated from a well-characterized transgenic mouse line, is described as a new tool for the identification of chemical teratogens and the characterization of relevant mechanisms of embryonic toxicity.

TL;DR: Investigating whether circadian synchronization of human cells in an in vitro system improves the cellular response and, thus, increases the sensitivity of the test system indicates that a synchronized circadian rhythm in a cell culture based test system can improve the physiological relevance of an appropriate in vitro method by reflecting the biological in vivo situation more closely.

TL;DR: The E-Morph Assay as discussed by the authors is a high-throughput screening-compatible image-based phenotypic screening assay that facilitates robust predictions of the estrogenic potential of environmental chemicals using quantitative changes in the cell-cell contact morphology of human breast cancer cells as a novel functional endpoint.