M
Michael Roggendorf
Researcher at Technische Universität München
Publications - 259
Citations - 11125
Michael Roggendorf is an academic researcher from Technische Universität München. The author has contributed to research in topics: Virus & Hepatitis B virus. The author has an hindex of 57, co-authored 258 publications receiving 10475 citations. Previous affiliations of Michael Roggendorf include University of Duisburg-Essen.
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Journal ArticleDOI
Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C
Jan M. Pestka,Mirjam B. Zeisel,Edith Bläser,Peter Schürmann,Birke Bartosch,François-Loïc Cosset,Arvind H. Patel,Helga Meisel,Jens Baumert,Sergei Viazov,Kay Rispeter,Hubert E. Blum,Michael Roggendorf,Thomas F. Baumert +13 more
TL;DR: It is suggested that rapid induction of neutralizing antibodies during the early phase of infection may contribute to control of HCV infection.
Journal ArticleDOI
Hepatitis B virus suppresses toll-like receptor–mediated innate immune responses in murine parenchymal and nonparenchymal liver cells
J Wu,Zhongji Meng,Min Jiang,Rongjuan Pei,Martin Trippler,Ruth Broering,Agnes Bucchi,Jan-Peter Sowa,Ulf Dittmer,Dongliang Yang,Michael Roggendorf,Guido Gerken,Mengji Lu,Joerg F. Schlaak +13 more
TL;DR: The data indicate that HBV can suppress the TLR‐induced antiviral activity of liver cells, which has major implications for the interaction between HBV and the immune system.
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Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice.
J Wu,Mengji Lu,Zhongji Meng,Martin Trippler,Ruth Broering,Agnes Szczeponek,Frank Krux,Ulf Dittmer,Michael Roggendorf,Guido Gerken,Joerg F. Schlaak +10 more
TL;DR: The data indicate that the innate immune system of the liver can control HBV replication after activation by TLR agonists, which has implications for the development of TLR‐based therapeutic approaches against HBV.
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Antibodies in Human Sera Specific to Hypervariable Region 1 of Hepatitis C Virus Can Block Viral Attachment
TL;DR: Findings suggest that the majority of neutralizing antibodies are directed against HVR1, the hypervariable region 1 within the putative envelop protein E2 of hepatitis C virus.
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Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection.
Jia Liu,Ejuan Zhang,Zhiyong Ma,Weimin Wu,Anna D. Kosinska,Xiaoyong Zhang,Inga Möller,Pia L. Seiz,Dieter Glebe,Baoju Wang,Dongliang Yang,Mengji Lu,Michael Roggendorf +12 more
TL;DR: In vivo blockade of PD-1/PD-L1 pathway on CD8 T cells, in combination with ETV treatment and DNA vaccination, potently enhanced the function of virus-specific T cells and led to sustained immunological control of viral infection, anti-WHs antibody development and complete viral clearance in some woodchucks.