Arvind H. Patel

TL;DR: Inhibition of RTK function may constitute a new approach for prevention and treatment of HCV infection and show that tyrosine kinase inhibitors have substantial antiviral activity.

TL;DR: It is suggested that rapid induction of neutralizing antibodies during the early phase of infection may contribute to control of HCV infection.

TL;DR: The authors identified shared biology and host-directed drug targets to prioritize therapeutics with potential for rapid deployment against current and future coronavirus outbreaks, and found that individuals with genotypes corresponding to higher soluble IL17RA levels in plasma are at decreased risk of COVID-19 hospitalization.

TL;DR: It is found that p7 is essential for efficient assembly and release of infectious virions across divergent virus strains, and p7 variants from different isolates deviate substantially in their capacity to promote virus production, suggesting that p 7 is an important virulence factor that may modulate fitness and in turn virus persistence and pathogenesis.

TL;DR: Identification of a broadly neutralizing antibody that recognizes a linear epitope is likely to be of significant benefit to future vaccine and therapeutic antibody development.