M
Michael Shaw
Researcher at National Physical Laboratory
Publications - 60
Citations - 743
Michael Shaw is an academic researcher from National Physical Laboratory. The author has contributed to research in topics: Microscope & Microscopy. The author has an hindex of 14, co-authored 49 publications receiving 533 citations. Previous affiliations of Michael Shaw include University College London & Engineering and Physical Sciences Research Council.
Papers
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Journal ArticleDOI
High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesicles.
Andrea Longatti,Christina Schindler,Andie Collinson,Lesley Jenkinson,Carl Anthony Matthews,Laura Fitzpatrick,Margaret Blundy,Ralph Minter,Tristan J. Vaughan,Michael Shaw,Natalie J. Tigue +10 more
TL;DR: The potential of single chain variable fragments (scFv) as targeting domains to achieve delivery of exosomes to cells expressing a cognate antigen is explored and it is demonstrated that targeting exosome to cells via a specific cell surface receptor can alter their intracellular trafficking route.
Journal ArticleDOI
Optimized approaches for optical sectioning and resolution enhancement in 2D structured illumination microscopy
Kevin O'Holleran,Michael Shaw +1 more
TL;DR: A linear reconstruction method is presented that maximizes the axial frequency extent of the combined 2D structured illumination passband along with an empirically optimized approximation to this scheme.
Journal ArticleDOI
High speed structured illumination microscopy in optically thick samples.
TL;DR: By combining a single plane reconstruction algorithm with hardware for high-speed switching between illumination patterns and rapid acquisition of fluorescence images, this paper demonstrates high speed super-resolution imaging inside biological organisms.
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Super-resolution microscopy as a potential approach to diagnosis of platelet granule disorders.
David Westmoreland,Michael Shaw,William Grimes,Daniel J. Metcalf,Jemima J. Burden,Keith Gomez,Alex E. Knight,Daniel F. Cutler +7 more
TL;DR: Super‐resolution microscopy facilitates the diagnosis of structural platelet disorders and, using CD63 as a marker, Hermansky‐Pudlak patients are easily distinguished from controls.
Journal ArticleDOI
Engineering Chirally Blind Protein Pseudocapsids into Antibacterial Persisters
Ibolya E. Kepiro,Irene Marzuoli,Irene Marzuoli,Katharine Hammond,Katharine Hammond,Katharine Hammond,Xiaoliang Ba,Helen Lewis,Michael Shaw,Michael Shaw,Smita B. Gunnoo,Emiliana De Santis,Urszula Łapińska,Stefano Pagliara,Mark A. Holmes,Christian D. Lorenz,Bart W. Hoogenboom,Bart W. Hoogenboom,Franca Fraternali,Maxim G. Ryadnov,Maxim G. Ryadnov +20 more
TL;DR: A conceptual design of protein pseudo-capsids exhibiting a broad spectrum of antimicrobial activities is reported, which are effective against phenotypic bacterial variants, while clearing "superbugs" in vivo without toxicity.