Michael Shum

TL;DR: It is concluded that PDM represent a segregated mitochondrial population with unique structure and function that supports triacylglyceride synthesis.

TL;DR: The role of AMPK in skeletal muscle during exercise and in exercise recovery is focused on and adaptations to exercise training, including skeletal muscle plasticity, are addressed, highlighting novel concepts and future perspectives that need to be investigated.

TL;DR: Six neuronal populations in the mouse VMH are described by using single-cell RNA transcriptomics and in situ hybridization to reveal a role for Rprm in temperature regulation and ERα in the masculinization of neuron populations that underlie energy expenditure.

TL;DR: Results indicate that AT2R is involved in early adipocyte differentiation, while in mature adipocytes and in a model of insulin resistance AT1R activation restores normal adipocyte morphology and improves insulin sensitivity.

TL;DR: While rapamycin treatment induced glucose intolerance and failed to improve Akt phosphorylation in liver and muscle of HF-fed mice, PF-4708671 treatment improved glucose tolerance and increased Akt phosphorus in metabolic tissues of these obese mice, suggesting that specific S6K1 blockade is a valid pharmacological approach to improve glucose disposal in obese diabetic individuals.