J
Jakob D. Wikstrom
Researcher at Karolinska University Hospital
Publications - 46
Citations - 6622
Jakob D. Wikstrom is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Mitochondrion & Autophagy. The author has an hindex of 23, co-authored 43 publications receiving 5727 citations. Previous affiliations of Jakob D. Wikstrom include Stockholm University & Tufts University.
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Journal ArticleDOI
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Gilad Twig,Alvaro A. Elorza,Anthony J.A. Molina,Anthony J.A. Molina,Hibo Mohamed,Jakob D. Wikstrom,Gil Walzer,Linsey Stiles,Sarah E. Haigh,Steve Katz,Guy Las,Joseph Alroy,Min Wu,Bénédicte F. Py,Junying Yuan,Jude T. Deeney,Barbara E. Corkey,Orian S. Shirihai +17 more
TL;DR: Pulse chase and arrest of autophagy at the pre‐proteolysis stage reveal that fission followed by selective fusion segregates dysfunctional mitochondria and permits their removal by autophagic.
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The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
Lei Zhong,Agustina D’Urso,Debra Toiber,Carlos Sebastian,Ryan E. Henry,Douangsone D. Vadysirisack,Alexander R. Guimaraes,Brett Marinelli,Jakob D. Wikstrom,Jakob D. Wikstrom,Tomer Nir,Clary B. Clish,Bhavapriya Vaitheesvaran,Othon Iliopoulos,Irwin J. Kurland,Yuval Dor,Ralph Weissleder,Orian S. Shirihai,Leif W. Ellisen,Joaquín M. Espinosa,Raul Mostoslavsky +20 more
TL;DR: It is demonstrated that SIRT6 functions as a histone H3K9 deacetylase to control the expression of multiple glycolytic genes, and appears to function as a corepressor of the transcription factor Hif1alpha, a critical regulator of nutrient stress responses.
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Mitochondrial Networking Protects β-Cells From Nutrient-Induced Apoptosis
Anthony J.A. Molina,Jakob D. Wikstrom,Jakob D. Wikstrom,Linsey Stiles,Linsey Stiles,Guy Las,Hibo Mohamed,Alvaro A. Elorza,Gil Walzer,Gilad Twig,Steve Katz,Barbara E. Corkey,Orian S. Shirihai +12 more
TL;DR: Data suggest that alterations in mitochondrial fusion and fission play a critical role in nutrient-induced β-cell apoptosis and may be involved in the pathophysiology of type 2 diabetes.
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Dual role of proapoptotic BAD in insulin secretion and beta cell survival
Nika N. Danial,Loren D. Walensky,Chen-Yu Zhang,Cheol Soo Choi,Jill K. Fisher,Anthony J.A. Molina,Sandeep Robert Datta,Sandeep Robert Datta,Kenneth L. Pitter,Gregory H. Bird,Jakob D. Wikstrom,Jude T. Deeney,Kirsten Robertson,Joel Morash,Ameya Kulkarni,Susanne Neschen,Sheene Kim,Michael E. Greenberg,Barbara E. Corkey,Orian S. Shirihai,Gerald I. Shulman,Bradford B. Lowell,Stanley J. Korsmeyer,Stanley J. Korsmeyer +23 more
TL;DR: In this article, the proapoptotic BCL-2 family member BAD resides in a glucokinase-containing complex that regulates glucose-driven mitochondrial respiration, which is specifically dependent upon the phosphorylation of its BH3 sequence, previously defined as an essential death domain.
Journal ArticleDOI
Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion
Ilan Y. Benador,Ilan Y. Benador,Michaela Veliova,Kiana Mahdaviani,Anton Petcherski,Jakob D. Wikstrom,Jakob D. Wikstrom,Essam A. Assali,Essam A. Assali,Rebeca Acín-Pérez,Michael Shum,Marcus F. Oliveira,Saverio Cinti,Carole Sztalryd,William D. Barshop,James A. Wohlschlegel,Barbara E. Corkey,Marc Liesa,Orian S. Shirihai,Orian S. Shirihai,Orian S. Shirihai +20 more
TL;DR: It is concluded that PDM represent a segregated mitochondrial population with unique structure and function that supports triacylglyceride synthesis.