M
Michael Wallace
Researcher at Bristol-Myers Squibb
Publications - 11
Citations - 151
Michael Wallace is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Carboxylation & Adduct. The author has an hindex of 4, co-authored 11 publications receiving 100 citations.
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Journal ArticleDOI
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)
Scott H. Watterson,Qingjie Liu,Myra Beaudoin Bertrand,Douglas G. Batt,Ling Li,Mark A. Pattoli,Stacey Skala,Lihong Cheng,Mary T. Obermeier,Robin Moore,Zheng Yang,Rodney Vickery,Paul A. Elzinga,Lorell Discenza,Celia D’Arienzo,Kathleen M. Gillooly,Tracy L. Taylor,Claudine Pulicicchio,Yifan Zhang,Elizabeth M. Heimrich,Kim W. McIntyre,Qian Ruan,Richard A. Westhouse,Ian M. Catlett,Naiyu Zheng,Charu Chaudhry,Jun Dai,Michael Galella,Andrew J. Tebben,Matt Pokross,Jianqing Li,Rulin Zhao,Daniel Smith,Richard Rampulla,Alban Allentoff,Michael Wallace,Arvind Mathur,Luisa Salter-Cid,John E. Macor,Percy H. Carter,Aberra Fura,James R. Burke,Joseph A. Tino +42 more
TL;DR: The evolution of the strategy to identify a covalent, irreversible inhibitor of BTK that has the intrinsic potency, selectivity, and pharmacokinetic properties necessary to provide a rapid rate of inactivation systemically following a very low dose is outlined.
Journal ArticleDOI
Direct Carbon Isotope Exchange through Decarboxylative Carboxylation
Cian Kingston,Michael Wallace,Alban Allentoff,Justine N. deGruyter,Jason S. Chen,Sharon Gong,Samuel J. Bonacorsi,Phil S. Baran +7 more
TL;DR: A two-step degradation-reconstruction approach to the carbon-14 radiolabeling of alkyl carboxylic acids is presented to afford a range of complex compounds with ample isotopic incorporations for drug metabolism and pharmacokinetic studies.
Journal ArticleDOI
Adnectin-drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors.
Dasa Lipovsek,Irvith M. Carvajal,Alban Allentoff,Anthony Barros,John A. Brailsford,Qiang Cong,Pete Z. Cotter,Sanjeev Gangwar,Cris Hollander,Virginie Lafont,Wai Leung Lau,Wenying Li,Miguel Moreta,O'neil Steven,Jason Pinckney,Michael J. Smith,Julie Su,Christina Terragni,Michael Wallace,Lifei Wang,Martin C. Wright,H. Nicholas Marsh,James William Bryson +22 more
TL;DR: Adnectin–drug conjugates are presented, an alternative platform for tumor-specific delivery of cytotoxic payloads and its high thermostability, its localization to target-expressing tumor cells in vitro and in vivo, its fast clearance from normal tissues and its efficacy against Glypican-3-positive mouse xenograft models.
Journal ArticleDOI
Chemoselective Methionine Bioconjugation: Site-Selective Fluorine-18 Labeling of Proteins and Peptides.
Daniel Lin,Michael Wallace,Alban Allentoff,David J. Donnelly,Erin Gomes,Kim Voronin,Sharon Gong,Richard Y.-C. Huang,Ho Kim,Janet Caceres-Cortes,Samuel J. Bonacorsi +10 more
TL;DR: The results establish the viability of chemoselective methionine bioconjugation as a method for preparing site-selective 18F-labeled PET radioligands.
Journal Article
Radiochemistry challenges and progression for incorporation of 18F into a complex substituted 6-18F-fluoroquinoline BMS-986205 for IDO imaging
Erin L. Cole,David J. Donnelly,Michael Wallace,Tritin Tran,Richard C. Burrell,Wesley A. Turley,Alban Allentoff,Audris Huang,Aaron Balog,Samuel J. Bonacorsi +9 more
TL;DR: The goal was to develop a translatable method for late-stage nucleophilic fluorination of BMS-986205 suitable for clinical use and validated for use in clinical studies.