M
Michaela Vorlíčková
Researcher at Academy of Sciences of the Czech Republic
Publications - 82
Citations - 4491
Michaela Vorlíčková is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: DNA & G-quadruplex. The author has an hindex of 28, co-authored 80 publications receiving 3954 citations. Previous affiliations of Michaela Vorlíčková include Central European Institute of Technology.
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Journal ArticleDOI
Circular dichroism and conformational polymorphism of DNA
TL;DR: Here the authors review studies that provided important information about conformational properties of DNA using circular dichroic (CD) spectroscopy, which significantly participated in all basic conformational findings on DNA.
Journal ArticleDOI
Circular dichroism and guanine quadruplexes
Michaela Vorlíčková,Iva Kejnovská,Iva Kejnovská,Janos Sagi,Daniel Renčiuk,Daniel Renčiuk,Klára Bednářová,Jitka Motlová,Jaroslav Kypr,Jaroslav Kypr +9 more
TL;DR: It is shown that CD Spectroscopy is an important complementary technique to NMR spectroscopy and X-ray diffraction in quadruplex studies.
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Circular dichroism spectroscopy of DNA: from duplexes to quadruplexes.
Michaela Vorlíčková,Michaela Vorlíčková,Iva Kejnovská,Klára Bednářová,Daniel Renčiuk,Jaroslav Kypr +5 more
TL;DR: CD spectra of nucleic acids are reviewed, beginning with early studies on natural DNA molecules through analyses of synthetic polynucleotides to study of selected genomic fragments.
Journal ArticleDOI
Arrangements of human telomere DNA quadruplex in physiologically relevant K+ solutions
Daniel Renčiuk,Iva Kejnovská,Petra Školáková,Klára Bednářová,Jitka Motlová,Michaela Vorlíčková +5 more
TL;DR: It is demonstrated that the same transitions can be induced even in aqueous, K+-containing solution by increasing the DNA concentration, which is why distinct quadruplex structures were detected for AG3(TTAG3)3 by X-ray, nuclear magnetic resonance and circular dichrosim spectroscopy.
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Guanine tetraplex topology of human telomere DNA is governed by the number of (TTAGGG) repeats
TL;DR: With an increasing repeat number, the fragment tetraplexes surprisingly are ever less thermostable and their migration and enthalpy decrease indicate increasing irregularities or domain splitting in their arrangements.