Michaela Vorlíčková

TL;DR: In this article, a series of DNA oligonucleotides comprising GAGA segment and C3 clip is analyzed by NMR and CD spectroscopies to understand the sequence-structure-stability relationships.

TL;DR: Lesion in one guanine tract of a more than four repeats long human telomere DNA sequence may cause re-positioning of its quadruplex arrangement associated with a shift of the structure to less common quadruplex conformations.

TL;DR: The simulations suggest that a minimum of three quartets are needed to form an intrinsically stable all-anti parallel-stranded DNA GQ in the presence of Na+ or K+ ions, and predict that isolated RNA two-quartet parallel GQs may form, albeit being weakly stable.

TL;DR: It is shown that parallel quadruplexes are significantly more sensitive towards guanine substitutions than antiparallel ones, and Guanine-substituted variants, which in principle might correspond to native genomic sequences, distinctly differ in their biophysical properties, indicating that the four guanines in each tetrad of parallel quadru Plexes are not equal.

TL;DR: In this article, the structural diversity of cytosine (C)-rich oligodeoxynucleotides (ODNs) arising from their detail nucleotide sequence and experimental conditions was analyzed.