Journal ArticleDOI
Circular dichroism spectroscopy of DNA: from duplexes to quadruplexes.
Michaela Vorlíčková,Michaela Vorlíčková,Iva Kejnovská,Klára Bednářová,Daniel Renčiuk,Jaroslav Kypr +5 more
TLDR
CD spectra of nucleic acids are reviewed, beginning with early studies on natural DNA molecules through analyses of synthetic polynucleotides to study of selected genomic fragments.About:
This article is published in Chirality.The article was published on 2012-09-01. It has received 243 citations till now. The article focuses on the topics: Nucleic acid structure & Circular dichroism.read more
Citations
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G-Quadruplex Secondary Structure Obtained from Circular Dichroism Spectroscopy.
TL;DR: The results show that CD spectra of nucleic acids can be analyzed to obtain quantitative structural information about secondary structure content in an analogous way to methods used to analyze proteinCD spectra.
Journal ArticleDOI
A novel colorimetric aptasensor using cysteamine-stabilized gold nanoparticles as probe for rapid and specific detection of tetracycline in raw milk
TL;DR: In this article, a sensitive and specific colorimetric aptasensor for rapid detection of tetracycline (TET) in raw milk was developed by using cysteamine-stabilized gold nanoparticles (CS-AuNPs) as the probe.
Journal ArticleDOI
Ultrasensitive colorimetric detection of 17β-estradiol: the effect of shortening DNA aptamer sequences.
Omar A. Alsager,Shalen Kumar,Bicheng Zhu,Jadranka Travas-Sejdic,Kenneth P. McNatty,Justin M. Hodgkiss +5 more
TL;DR: The performance advances achieved by specifically considering the signal transduction mechanism ultimately resulted in facile detection of E2 in urine, as well as enabling environmental detection in water and urine samples using DNA aptamer-coated gold nanoparticles (AuNPs), and retaining a small number of excess bases is optimal.
Journal ArticleDOI
Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression
Christine E. Kaiser,Natalie A. Van Ert,Prashansa Agrawal,Reena Chawla,Danzhou Yang,Laurence H. Hurley +5 more
TL;DR: The transcription factor heterogeneous nuclear ribonucleoprotein K was found to bind selectively to the i-motif species and to positively modulate KRAS transcription, and a benzophenanthridine alkaloid was identified that dissipates the hairpin species and destabilizes the interaction of hnRNP K with the Mid-region i-Motif.
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Catalytic Hairpin Assembly-Programmed Porphyrin–DNA Complex as Photoelectrochemical Initiator for DNA Biosensing
TL;DR: The CHA-programmed porphyrin-DNA strategy not only extends the applications of photoelectrochemistry, but also presents a novel methodology in bioanalysis.
References
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Journal ArticleDOI
Molecular structure of a left-handed double helical DNA fragment at atomic resolution
Andrew H.-J. Wang,Gary J. Quigley,F. Kolpak,J.L. Crawford,J. H. Van Boom,G. A. Van Der Marel,Alexander Rich +6 more
TL;DR: The DNA fragment d(CpGpCpC pGp CpG pG) crystallises as a left-handed double helical molecule with Watson–Crick base pairs and an antiparallel organisation of the sugar phosphate chains.
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Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
TL;DR: The evidence for G-quadruplexes in gene promoters is described and their potential as therapeutic targets are discussed, as well as progress in the development of strategies to harness this potential through intervention with small-molecule ligands.
Journal ArticleDOI
Circular dichroism and conformational polymorphism of DNA
TL;DR: Here the authors review studies that provided important information about conformational properties of DNA using circular dichroic (CD) spectroscopy, which significantly participated in all basic conformational findings on DNA.
Journal ArticleDOI
Structure of a B-DNA dodecamer: conformation and dynamics.
Horace R. Drew,Richard M. Wing,Tsunehiro Takano,Christopher Broka,Shoji Tanaka,Keiichi Itakura,Richard E. Dickerson +6 more
TL;DR: A tendency toward 2-fold symmetry in sugar conformation about the center of the molecule is detectable in spite of the destruction of ideal 2- fold symmetry by the molecular bending, and sugar conformations of paired based appear to follow a "principle of anticorrelation."
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Salt-induced co-operative conformational change of a synthetic DNA: Equilibrium and kinetic studies with poly(dG-dC)☆
Fritz M. Pohl,Thomas M. Jovin +1 more
TL;DR: The experiments show that an isomerization of DNA with a certain base sequence is possible in solution and the proposed model suggests a plausible mechanism.