H
Heike Brötz-Oesterhelt
Researcher at University of Tübingen
Publications - 81
Citations - 4411
Heike Brötz-Oesterhelt is an academic researcher from University of Tübingen. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 27, co-authored 65 publications receiving 3315 citations. Previous affiliations of Heike Brötz-Oesterhelt include Bayer & Bayer Corporation.
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Journal ArticleDOI
Human commensals producing a novel antibiotic impair pathogen colonization
Alexander Zipperer,Martin C. Konnerth,Claudia Laux,Anne Berscheid,Daniela Janek,Daniela Janek,Christopher Weidenmaier,Marc Burian,Nadine A. Schilling,Christoph Slavetinsky,Matthias Marschal,Matthias Willmann,Hubert Kalbacher,Birgit Schittek,Heike Brötz-Oesterhelt,Stephanie Grond,Andreas Peschel,Bernhard Krismer +17 more
TL;DR: It is shown that nasal Staphylococcus lugdunensis strains produce lugdunin, a novel thiazolidine-containing cyclic peptide antibiotic that prohibits colonization by S. aureus, and a rare example of a non-ribosomally synthesized bioactive compound from human-associated bacteria.
Journal ArticleDOI
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
Heike Brötz-Oesterhelt,Dieter Beyer,Hein-Peter Kroll,Rainer Endermann,Christoph Ladel,Werner Schroeder,Berthold Hinzen,Siegfried Raddatz,Holger Paulsen,Kerstin Henninger,Julia E. Bandow,Julia E. Bandow,Hans-Georg Sahl,Harald Labischinski +13 more
TL;DR: A new class of antibiotics is shown to have antibacterial activity against Gram-positive bacteria in vitro and in several rodent models of bacterial infection, implying a new target, which is identified as ClpP, the core unit of a major bacterial protease complex.
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Small cationic antimicrobial peptides delocalize peripheral membrane proteins
Michaela Wenzel,Alina Iulia Chiriac,Andreas Otto,Dagmar Zweytick,Caroline May,Catherine Schumacher,Ronald Gust,H. Bauke Albada,Maya Penkova,Ute Krämer,Ralf Erdmann,Nils Metzler-Nolte,Suzana K. Straus,Erhard Bremer,Dörte Becher,Heike Brötz-Oesterhelt,Hans-Georg Sahl,Julia E. Bandow +17 more
TL;DR: It is shown that peptide integration into the membrane causes delocalization of essential peripheral membrane proteins essential for respiration and cell-wall biosynthesis, limiting cellular energy and undermining cell- wall integrity.
Journal ArticleDOI
Towards the sustainable discovery and development of new antibiotics
Marcus Miethke,Marco Pieroni,Tilmann Weber,Mark Brönstrup,Peter Hammann,Ludovic Halby,Paola B. Arimondo,Philippe Glaser,Bertrand Aigle,Helge B. Bode,Helge B. Bode,Rui Moreira,Yanyan Li,Andriy Luzhetskyy,Marnix H. Medema,Jean-Luc Pernodet,Marc Stadler,José R. Tormo,Olga Genilloud,Andrew W. Truman,Kira J. Weissman,Eriko Takano,Stefano Sabatini,Evi Stegmann,Heike Brötz-Oesterhelt,Wolfgang Wohlleben,Myriam Seemann,Martin Empting,Anna K. H. Hirsch,Brigitta Loretz,Claus-Michael Lehr,Alexander Titz,Jennifer Herrmann,Timo Jaeger,Silke Alt,Thomas Hesterkamp,Mathias Winterhalter,Andrea Schiefer,Kenneth Pfarr,Achim Hoerauf,Heather Graz,Michael Graz,Mika Lindvall,Savithri Ramurthy,Anders Karlén,Maarten van Dongen,Hrvoje Petković,Andreas Keller,Frédéric Peyrane,Stefano Donadio,Laurent Fraisse,Laura J. V. Piddock,Ian H. Gilbert,Heinz E. Moser,Rolf Müller +54 more
TL;DR: In this paper, the authors present a strategic blueprint to substantially improve our ability to discover and develop new antibiotics, and propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding.
Journal ArticleDOI
The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease
Janine Kirstein,Janine Kirstein,Anja Hoffmann,Hauke Lilie,Ronny Schmidt,Helga Rübsamen-Waigmann,Heike Brötz-Oesterhelt,Axel Mogk,Kürşad Turgay +8 more
TL;DR: The molecular mechanism of ADEP action is analysed and it is demonstrated that ADEPs abrogate ClpP interaction with cooperating Hsp100 adenosine triphosphatases (ATPases) and cause a complete functional reprogramming of the Clp–protease complex.