Michal Melamed

TL;DR: Various types of studies associating ASD with the immune system are summarized, critically evaluate the quality of these studies, and attempt to integrate them in a way that clarifies the areas of immune and autoimmune phenomena in ASD research that will be important indicators for future research.

TL;DR: Results indicate that p60c-src can restore estrogen binding to the tyrosine-dephosphorylated hER and that dimerization and cooperative site-site interaction of the hER occur via a phosphotyrosin-binding interaction.

TL;DR: A review of recent autism gene expression studies highlights genes that are expressed in the brain, immune system, and processes such as cell metabolism and embryology as well as differences in gene expression levels between different types of biological tissues.

TL;DR: The dual agonist/antagonist properties of estriol are studied, using recombinant human estrogen receptor (hER) in ligand-binding assay, cell-free transcription assay, electrophoretic mobility shift assay with cVitII estrogen response element (ERE), and ERE-Sepharose chromatography to propose that when hER, estradiol, and estriOL are coequilibrated, several receptor species are formed.

TL;DR: Four compounds with ester, amine, amide, or alcohol side chains injected subcutaneously in mice at a dose of 1 μmol/kg or less prevented LPS-induced cytokine elevation in the brain and peripheral tissues and had anti-inflammatory activity at 1/100th of the concentration of unsubstituted indoline.