Journal ArticleDOI
Immunological and autoimmune considerations of Autism Spectrum Disorders
Benjamin Gesundheit,Joshua P. Rosenzweig,David Naor,Bernard Lerer,Ditza A. Zachor,Václav Procházka,Michal Melamed,Donald A. Kristt,Abraham Steinberg,Cory Shulman,Paul A. Hwang,Paul A. Hwang,Gideon Koren,Gideon Koren,Asnat Walfisch,Asnat Walfisch,Jacob Passweg,John A. Snowden,Ryad Tamouza,Marion Leboyer,D. Farge-Bancel,Paul Ashwood +21 more
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TLDR
Various types of studies associating ASD with the immune system are summarized, critically evaluate the quality of these studies, and attempt to integrate them in a way that clarifies the areas of immune and autoimmune phenomena in ASD research that will be important indicators for future research.About:
This article is published in Journal of Autoimmunity.The article was published on 2013-08-01. It has received 155 citations till now. The article focuses on the topics: Autism.read more
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An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options
TL;DR: This review provides a broad overview of the history, prevalence, etiology, clinical presentation, and heterogeneity of ASD and explores the potential of a new wave of research examining objective biomarkers to facilitate the evaluation of sub-typing, diagnosis, and treatment response in ASD.
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Autism genetics: opportunities and challenges for clinical translation.
Jacob A. S. Vorstman,Jeremy R. Parr,Daniel Moreno-De-Luca,Richard Anney,John I. Nurnberger,Joachim Hallmayer +5 more
TL;DR: Findings indicate that aetiological heterogeneity, variable penetrance and genetic pleiotropy are pervasive characteristics of autism genetics.
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The Role of the Immune System in Autism Spectrum Disorder.
TL;DR: A deeper understanding of the interaction between both maternal and child immune systems, and the role they have in diagnosis and treatment is required.
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Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism.
TL;DR: The evidence linking oxidative stress, mitochondrial dysfunction and immune dysregulation/inflammation in the brain of ASD individuals is examined, suggesting that ASD has a clear biological basis with features of known medical disorders.
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Prenatal Stress-Induced Increases in Placental Inflammation and Offspring Hyperactivity Are Male-Specific and Ameliorated by Maternal Antiinflammatory Treatment
TL;DR: An important interaction between maternal stress and a proinflammatory state in the long-term programming effects of maternal stress is supported.
References
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Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
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Advances in autism genetics: on the threshold of a new neurobiology
TL;DR: Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme.
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Transcriptomic analysis of autistic brain reveals convergent molecular pathology
Irina Voineagu,Xinchen Wang,Patrick Johnston,Jennifer K. Lowe,Yuan Tian,Steve Horvath,Jonathan Mill,Rita M. Cantor,Benjamin J. Blencowe,Daniel H. Geschwind +9 more
TL;DR: The results provide strong evidence for convergent molecular abnormalities in ASD, and implicate transcriptional and splicing dysregulation as underlying mechanisms of neuronal dysfunction in this disorder.
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Functional and anatomical cortical underconnectivity in autism: Evidence from an fMRI study of an executive function task and corpus callosum morphometry
Marcel Adam Just,Vladimir L. Cherkassky,Timothy A. Keller,Rajesh K. Kana,Nancy J. Minshew,Nancy J. Minshew +5 more
TL;DR: The brain activation of a group of high-functioning autistic participants was measured using functional magnetic resonance imaging during the performance of a Tower of London task, in comparison with a control group matched with respect to intelligent quotient, age, and gender to suggest underconnectivity in the group with autism.
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Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome.
Paul Ashwood,Paula Krakowiak,Irva Hertz-Picciotto,Robin L Hansen,Isaac N. Pessah,Judith A Van de Water +5 more
TL;DR: Evidence of differential cytokine release in plasma samples obtained from 2 to 5 year-old children with ASD compared with age-matched typically developing children and children with developmental disabilities other than autism (DD) is investigated and significantly shifted cytokine profiles are reported.