M
Michel Crépin
Researcher at French Institute of Health and Medical Research
Publications - 56
Citations - 1533
Michel Crépin is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Angiogenesis & Cell growth. The author has an hindex of 21, co-authored 56 publications receiving 1441 citations. Previous affiliations of Michel Crépin include University of Paris.
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Journal ArticleDOI
Elastin-derived peptides enhance angiogenesis by promoting endothelial cell migration and tubulogenesis through upregulation of MT1-MMP.
Arnaud Robinet,Abdel Fahem,Jean-Hubert Cauchard,Eric Huet,Loïc Vincent,Sandrine Lorimier,Franck Antonicelli,Claudine Soria,Michel Crépin,William Hornebeck,Georges Bellon +10 more
TL;DR: Batimastat, an inhibitor of furin convertase and timP-2, but not TIMP-1, totally abolished the influence of elastin-derived peptides (EDPs) on cell migration and tubulogenesis, thus favoring the involvement of MT1-MMP in such processes.
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FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway.
TL;DR: It is demonstrated that FGF-2 and TPA induce MMP-9 secretion in MCF-7 cells mainly through PKC-dependent activation of the Ras/ERK(1/2) signaling pathway.
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Antiangiogenic and antitumor activities of peptide inhibiting the vascular endothelial growth factor binding to neuropilin-1.
Anna Starzec,Roger Vassy,Antoine Martin,Marc Lecouvey,Mélanie Di Benedetto,Michel Crépin,Gérard Y Perret +6 more
TL;DR: ATWLPPR, a previously identified KDR-interacting peptide, was shown to inhibit the VEGF165 interactions with NRP-1 but not with KDR and to decrease the tumor angiogenesis and growth, thus validating, in vivo, N RP-1 as a possible target for antiangiogenic and antitumor agents.
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A novel αvβ3-blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis
Oscar H. P. Ramos,Alexandre Kauskot,Alexandre Kauskot,Márcia Regina Cominetti,Iga Bechyne,Iga Bechyne,Carmen Lucia S. Pontes,Fabrice Chareyre,Fabrice Chareyre,Jan Manent,Jan Manent,Roger Vassy,Marco Giovannini,Marco Giovannini,Chantal Legrand,Chantal Legrand,Heloisa S. Selistre-de-Araujo,Michel Crépin,Michel Crépin,Arnaud Bonnefoy,Arnaud Bonnefoy,Arnaud Bonnefoy +21 more
TL;DR: It is concluded that DisBa-01 is a potent new inhibitor of αvβ3-dependent adherence mechanisms involved in neo-vascularization and tumor metastasis processes.
Journal ArticleDOI
Proteomic detection of changes in protein synthesis induced by fibroblast growth factor-2 in MCF-7 human breast cancer cells.
Anne-Sophie Vercoutter-Edouart,Xavier Czeszak,Michel Crépin,Jérôme Lemoine,Bénoni Boilly,Xuefen Le Bourhis,Jean-Philippe Peyrat,Hubert Hondermarck +7 more
TL;DR: The functionality of HSP90 is strictly required in order to obtain FGF-2 mitogenic stimulation in MCF-7 cells, indicating the crucial role played by this molecular chaperone in the control of breast cancer cell growth.