M
Michel Grino
Researcher at French Institute of Health and Medical Research
Publications - 96
Citations - 4116
Michel Grino is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Adipose tissue & Vasopressin. The author has an hindex of 34, co-authored 92 publications receiving 3967 citations. Previous affiliations of Michel Grino include Institut national de la recherche agronomique.
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Maternal Undernutrition during Late Gestation Induces Fetal Overexposure to Glucocorticoids and Intrauterine Growth Retardation, and Disturbs the Hypothalamo-Pituitary Adrenal Axis in the Newborn Rat1
TL;DR: The effects of maternal 50% food restriction in rats during the last week of gestation on the hypothalamo-pituitary adrenal (HPA) axis activity in both mothers and their fetuses were investigated.
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Expression of the mRNA Coding for 11β-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue from Obese Patients: An in Situ Hybridization Study
TL;DR: Observations suggest that an overexpression of 11beta-HSD-1 may explain part of the glucocorticoid-induced metabolic disorders linked to obesity and may promote visceral fat deposition.
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Stromal cells are the main plasminogen activator inhibitor-1-producing cells in human fat: evidence of differences between visceral and subcutaneous deposits.
Delphine Bastelica,Pierre Morange,Bruno Berthet,Hélène Borghi,Odile Lacroix,Michel Grino,Irène Juhan-Vague,Marie-Christine Alessi +7 more
TL;DR: It is demonstrated that PAI‐1 production is mainly due to stromal cells, which were more numerous in the visceral than in the subcutaneous depot, which could explain the strong relationship observed between circulating PAI-1 levels and the accumulation of visceral fat.
Journal Article
Corticotropin releasing factor
Bernard Conte-Devolx,Charles Oliver,Rey M,Guillaume,Elias Castanas,Giraud P,Françoise Boudouresque,Michel Grino +7 more
TL;DR: The search for a neurohormone specifically controlling ACTH secretion resulted in the discovery of the corticotropin-releasing factor, which is the predominant component of a complex control system of adrenal cortex secretion, which also includes catecholamines and the antidiuretic hormone.
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Postnatal diet-induced obesity in rats upregulates systemic and adipose tissue glucocorticoid metabolism during development and in adulthood: its relationship with the metabolic syndrome.
Sandrine Boullu-Ciocca,Anne Dutour,Viviane Guillaume,Vincent Achard,Charles Oliver,Michel Grino +5 more
TL;DR: The experimental paradigm of postnatal overfeeding is a powerful tool to understand the pathophysiology of glucocorticoid-induced programming of metabolic axes and leads to permanent upregulation of the HPA axis and increased adipose tissue glucoc Corticoid sensitivity.