Open AccessJournal Article
Corticotropin releasing factor
Bernard Conte-Devolx,Charles Oliver,Rey M,Guillaume,Elias Castanas,Giraud P,Françoise Boudouresque,Michel Grino +7 more
TLDR
The search for a neurohormone specifically controlling ACTH secretion resulted in the discovery of the corticotropin-releasing factor, which is the predominant component of a complex control system of adrenal cortex secretion, which also includes catecholamines and the antidiuretic hormone.Abstract:
The search for a neurohormone specifically controlling ACTH secretion resulted in the discovery of the corticotropin-releasing factor (CRF). This factor, located mainly in a paraventricular-infundibular hypothalamic tract, stimulates ACTH synthesis and secretion through a cAMP-dependent mechanism. The corticotropin-releasing factor is the predominant component of a complex control system of adrenal cortex secretion, which also includes catecholamines and the antidiuretic hormone. Its specificity as stimulant of the corticotropic function makes it an extremely useful tool for physiological and physiopathological studies of the hypothalamus-pituitary-adrenal cortex axis regulation.read more
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The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes.
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Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse
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Corticotropin-releasing factor immunoreactivity is widely distributed within the central nervous system of the rat: an immunohistochemical study
TL;DR: C corticotropin-releasing factor, like many other neurohormones and peptides, may participate in neuroendocrine regulation as well as play a role as a neurotransmitter-like substance in numerous extrahypothalamic circuits.