Michel Kather

TL;DR: In this article, a polycyclic aromatic precursor undergoes extensive enzymatic oxidative rearrangement catalyzed by two flavoprotein monooxygenases and a flavouroprotein oxidase that ultimately results in a drastic distortion of the carbon skeleton.

TL;DR: An effective dose range between 50 and 100 ng/ml after burst release is suggested for the CI insertion trauma model, and dexamethasone can be released from silicone electrode carrier dummies in a controlled and sustained way over a period of several weeks, leading to constant drug concentrations in the scala tympani perilymph.

TL;DR: A method for modified nucleosides covering 37 species is reported that could discriminate different subtypes of pancreatic cancer cell lines and could clearly be separated from a pancreatic control cell line as well as blank medium.

TL;DR: XD14 is a 4-acyl pyrrole derivative, which was discovered by a high-throughput virtual screening experiment as mentioned in this paper, and it inhibits bromodomain and extra-terminal domain (BET) proteins (BRD2, BRD3 and BRD4) and consequently suppresses cell proliferation.

TL;DR: In this paper , a tool compound was designed as a low molecular weight CRP inhibitor using the structure of phosphocholine as a template, and in vitro and in vivo proof-of-concept data demonstrating that the tool compound inhibits CRP-driven exacerbation of local inflammatory responses, while potentially preserving pathogen-defense functions of CRP.