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Britta Frensch
Researcher at University of Freiburg
Publications - 3
Citations - 30
Britta Frensch is an academic researcher from University of Freiburg. The author has contributed to research in topics: Polyketide & Modulation (music). The author has an hindex of 2, co-authored 2 publications receiving 13 citations.
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Journal ArticleDOI
Oxidative Carbon Backbone Rearrangement in Rishirilide Biosynthesis.
Olga Tsypik,Roman Makitrynskyy,Britta Frensch,David L. Zechel,Thomas Paululat,Robin Teufel,Andreas Bechthold +6 more
TL;DR: In conclusion, gene deletion experiments and in vitro enzyme studies are employed to identify key biosynthetic intermediates and expose intricate redox tailoring steps for the formation of rishirilide A, B, and D and lupinacidin A.
Journal ArticleDOI
Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides.
Britta Frensch,Thorsten Lechtenberg,Michel Kather,Zeynep Yunt,Martin U. Betschart,Bernd Kammerer,Steffen Lüdeke,Michael Müller,Jörn Piel,Robin Teufel +9 more
TL;DR: In this article, a polycyclic aromatic precursor undergoes extensive enzymatic oxidative rearrangement catalyzed by two flavoprotein monooxygenases and a flavouroprotein oxidase that ultimately results in a drastic distortion of the carbon skeleton.
Journal ArticleDOI
An acetyltransferase controls the metabolic flux in rubromycin polyketide biosynthesis by direct modulation of redox tailoring enzymes
TL;DR: A novel regulatory principle for natural products involving a dedicated acetyltransferase, which modifies a redox-tailoring enzyme and thereby enables pathway furcation and alternating pharmacophore assembly in rubromycin polyketide biosynthesis is reported.