B
Bernd Kammerer
Researcher at University of Freiburg
Publications - 120
Citations - 3735
Bernd Kammerer is an academic researcher from University of Freiburg. The author has contributed to research in topics: Clorobiocin & Metabolome. The author has an hindex of 32, co-authored 112 publications receiving 3137 citations. Previous affiliations of Bernd Kammerer include University of Tübingen & University of Applied Sciences Biberach.
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Journal ArticleDOI
Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat
Raffaele Teperino,Sabine Amann,Martina Bayer,Sean L. McGee,Andrea Loipetzberger,Timothy Connor,Carsten Jaeger,Bernd Kammerer,Lilli Winter,Gerhard Wiche,Kevin Dalgaard,Madhan Selvaraj,Michael Gaster,Robert S. Lee-Young,Mark A. Febbraio,Claude Knauf,Patrice D. Cani,Fritz Aberger,Josef M. Penninger,J. Andrew Pospisilik,Harald Esterbauer +20 more
TL;DR: It is shown that hedgehog signaling rewires cellular metabolism and is identified a cilium-dependent Smo-Ca(2+)-Ampk axis that triggers rapid Warburg-like metabolic reprogramming within minutes of activation and is required for proper metabolic selectivity and flexibility.
Journal ArticleDOI
Dexamethasone concentration gradients along scala tympani after application to the round window membrane.
TL;DR: The existence of substantial basal-apical concentration gradients of Dex-P in ST perilymph were demonstrated experimentally and may contribute to the heterogeneity of outcome that is observed after intratympanic application of glucocorticoids for various inner ear diseases.
Journal ArticleDOI
SIRT3 deficiency impairs mitochondrial and contractile function in the heart
Christoph Koentges,Katharina Pfeil,Tilman Schnick,Sebastian Wiese,Rabea Dahlbock,Maria C. Cimolai,Maximilian Meyer-Steenbuck,Katarina Cenkerova,Michael M. Hoffmann,Carsten Jaeger,Katja E. Odening,Bernd Kammerer,Lutz Hein,Christoph Bode,Heiko Bugger +14 more
TL;DR: SIRT3−/− mice developed progressive age-related deterioration of cardiac function, as evidenced by a decrease in ejection fraction and an increase in enddiastolic volume at 24 but not 8 weeks of age using echocardiography.
Journal ArticleDOI
CloQ, a prenyltransferase involved in clorobiocin biosynthesis
Florence Pojer,Emmanuel Wemakor,Bernd Kammerer,Huawei Chen,Christopher T. Walsh,Shu-Ming Li,Lutz Heide +6 more
TL;DR: The enzyme involved in the biosynthesis of ring A (3-dimethylallyl-4-hydroxybenzoic acid) is a soluble, monomeric 35-kDa protein, encoded by the structural gene cloQ, and seems to belong to a new class of prenyltransferases.
Journal Article
Abstract 14989: SIRT3 Deficiency Impairs Mitochondrial and Contractile Function in the Heart
Christoph Koentges,Katharina Pfeil,Tilman Schnick,Katarina Cenkerova,Carsten Jaeger,Bernd Kammerer,Lutz Hein,Christoph Bode,Heiko Bugger +8 more
TL;DR: Lack of SIRT3 impairs mitochondrial and contractile function in the heart, likely due to increased acetylation of various energy metabolic proteins and subsequent myocardial energy depletion.