M
Michela Pellegrini
Researcher at University of Siena
Publications - 15
Citations - 726
Michela Pellegrini is an academic researcher from University of Siena. The author has contributed to research in topics: Signal transduction & Jurkat cells. The author has an hindex of 10, co-authored 11 publications receiving 684 citations.
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Journal ArticleDOI
Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases.
Raffaella Ghittoni,Laura Patrussi,Katja Pirozzi,Michela Pellegrini,P.E. Lazzerini,P. Leopoldo Capecchi,Franco Laghi Pasini,Cosima T. Baldari +7 more
TL;DR: It is reported that simvastatin suppresses T‐cell activation and proliferation as the result of its capacity to inhibit HMG‐CoA reductase, and identifies Ras superfamily GTPases as strategic molecular targets in T‐ cell immunosuppression by statins.
Journal ArticleDOI
Extensive temporally regulated reorganization of the lipid raft proteome following T-cell antigen receptor triggering.
Luca Bini,Sonia Pacini,Sabrina Liberatori,Silvia Valensin,Michela Pellegrini,R. Raggiaschi,Vitaliano Pallini,Cosima T. Baldari +7 more
TL;DR: The data identify lipid rafts as highly dynamic structures and reveal a dramatic impact of surface TCR triggering not only on components of the TCR signalling machinery but also on proteins implicated in a number of diverse cellular processes.
Journal ArticleDOI
p66SHC Promotes Apoptosis and Antagonizes Mitogenic Signaling in T Cells
Sonia Pacini,Michela Pellegrini,Enrica Migliaccio,Laura Patrussi,Cristina Ulivieri,Andrea Ventura,Fabio Carraro,Antonella Naldini,Luisa Lanfrancone,Pier Giuseppe Pelicci,Cosima T. Baldari +10 more
TL;DR: The authors showed that p66Shc expression results in increased susceptibility to apoptogenic stimuli, which depends on Ser36 phosphorylation and correlates with an altered balance in apoptosis-regulating gene expression.
Journal ArticleDOI
p66SHC: the apoptotic side of Shc proteins.
TL;DR: This work focuses on the 66 kDa isoform of ShcA, whose paramount importance in the regulation of oxidative stress responses leading to cell apoptosis and ageing has been by now firmly established.
Journal ArticleDOI
Apoptosis and oxidative stress-related diseases: the p66Shc connection.
TL;DR: The multifaceted role of p66 Shc in redox regulation will be discussed, with a focus on the mechanisms underlying p66Shc-dependent apoptosis and its role in oxidative stress-related diseases.