M
Michelle A. Loprieno
Researcher at Fred Hutchinson Cancer Research Center
Publications - 17
Citations - 457
Michelle A. Loprieno is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Virus & Herpes simplex virus. The author has an hindex of 10, co-authored 15 publications receiving 282 citations. Previous affiliations of Michelle A. Loprieno include University of Washington.
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Journal ArticleDOI
SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98.
Amin Addetia,Nicole A P Lieberman,Quynh Phung,Tien-Ying Hsiang,Hong Xie,Pavitra Roychoudhury,Lasata Shrestha,Michelle A. Loprieno,Meei-Li Huang,Michael Gale,Keith R. Jerome,Keith R. Jerome,Alexander L. Greninger,Alexander L. Greninger +13 more
TL;DR: In this paper, the Sarbecovirus accessory protein ORF6 has been shown to be a major inhibitor of interferon production in both severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-coV-2.
Journal ArticleDOI
Validation of SARS-CoV-2 detection across multiple specimen types.
Garrett A. Perchetti,Arun K. Nalla,Meei-Li Huang,Haiying Zhu,Yulun Wei,Larry Stensland,Michelle A. Loprieno,Keith R. Jerome,Alexander L. Greninger,Alexander L. Greninger +9 more
TL;DR: A modified CDC-based laboratory developed test is able to detect SARSCoV- 2 accurately with similar sensitivity across all sample types tested, and the N2 gene target was found to be most sensitive in CSF.
Journal ArticleDOI
CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice.
Daniel Stone,Kelly R. Long,Michelle A. Loprieno,Harshana S. De Silva Feelixge,Elizabeth J. Kenkel,R. Matt Liley,Stephen R. Rapp,Pavitra Roychoudhury,Thuy Nguyen,Laurence Stensland,Rossana Colón-Thillet,Lindsay M. Klouser,Nicholas D. Weber,Connie Le,Jessica Wagoner,Erin A. Goecker,Alvason Zhenhua Li,Karsten Eichholz,Lawrence Corey,Lawrence Corey,D. Lorne Tyrrell,Alexander L. Greninger,Meei-Li Huang,Stephen J. Polyak,Martine Aubert,John E. Sagartz,Keith R. Jerome,Keith R. Jerome +27 more
TL;DR: HBV-specific AAV-SaCas9 therapy significantly improved survival of human hepatocytes, showed a trend toward decreasing total liver HBV DNA and cccDNA, and was well tolerated.
Journal ArticleDOI
Development of an ELISA to detect the secreted prostate cancer biomarker AGR2 in voided urine.
Elizabeth A. Wayner,Sue Ing Quek,Rumana Ahmad,Melissa E. Ho,Michelle A. Loprieno,Yong Zhou,William J. Ellis,Lawrence D. True,Alvin Y. Liu +8 more
TL;DR: Comparative transcriptomics between sorted cells identified AGR2 as one of the highest up‐regulated genes in cancer and overexpression in primary tumors was verified by tissue microarray analysis.
Journal ArticleDOI
Gene editing and elimination of latent herpes simplex virus in vivo
Martine Aubert,Daniel E. Strongin,Pavitra Roychoudhury,Michelle A. Loprieno,Anoria K. Haick,Lindsay M. Klouser,Laurence Stensland,Meei-Li Huang,Negar Makhsous,Alexander Tait,Harshana S. De Silva Feelixge,Roman Galetto,Philippe Duchateau,Alexander L. Greninger,Daniel Stone,Keith R. Jerome,Keith R. Jerome +16 more
TL;DR: A promising antiviral therapy based on gene editing with adeno-associated virus-delivered meganucleases leads to a significant reduction in ganglionic HSV loads and HSV reactivation, and may offer a pathway to a cure for HSV infection.