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Amin Addetia
Researcher at University of Washington
Publications - 49
Citations - 2761
Amin Addetia is an academic researcher from University of Washington. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 14, co-authored 35 publications receiving 985 citations. Previous affiliations of Amin Addetia include Seattle Children's & University of Washington Medical Center.
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Journal ArticleDOI
Prospective mapping of viral mutations that escape antibodies used to treat COVID-19.
Tyler N. Starr,Allison J. Greaney,Allison J. Greaney,Amin Addetia,Amin Addetia,William W. Hannon,William W. Hannon,Manish Chandra Choudhary,Adam S. Dingens,Jonathan Z. Li,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom +12 more
TL;DR: In this article, the authors map how all mutations to the receptor binding domain (RBD) of SARS-CoV-2 affect binding by the antibodies in the REGN-COV2 cocktail and the antibody LYCoV016.
Journal ArticleDOI
Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate.
Amin Addetia,Katharine H.D. Crawford,Katharine H.D. Crawford,Adam S. Dingens,Haiying Zhu,Pavitra Roychoudhury,Pavitra Roychoudhury,Meei Li Huang,Meei Li Huang,Keith R. Jerome,Keith R. Jerome,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom,Alexander L. Greninger,Alexander L. Greninger +15 more
TL;DR: The development of vaccines against SARS-CoV-2 would be greatly facilitated by the identification of immunological correlates of protection in humans, as the presence of neutralizing antibodies from prior infection was significantly associated with protection against reinfection.
Journal ArticleDOI
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.
Tyler N. Starr,Nadine Czudnochowski,Zhuoming Liu,Fabrizia Zatta,Young-Jun Park,Amin Addetia,Dora Pinto,Martina Beltramello,Patrick Hernandez,Allison J. Greaney,Allison J. Greaney,Roberta Marzi,William G. Glass,Ivy Zhang,Ivy Zhang,Adam S. Dingens,John E. Bowen,M. Alejandra Tortorici,Alexandra C. Walls,Jason A. Wojcechowskyj,Anna De Marco,Laura E. Rosen,Jiayi Zhou,Martin Montiel-Ruiz,Hannah Kaiser,Josh Dillen,Heather Tucker,Jessica Bassi,Chiara Silacci-Fregni,Michael P. Housley,Julia di Iulio,Gloria Lombardo,Maria L. Agostini,Nicole Sprugasci,Katja Culap,Stefano Jaconi,Marcel Meury,Exequiel Dellota,Rana Abdelnabi,Shi-Yan Caroline Foo,Elisabetta Cameroni,Spencer Stumpf,Tristan I. Croll,Jay C. Nix,Colin Havenar-Daughton,Luca Piccoli,Fabio Benigni,Johan Neyts,Amalio Telenti,Florian A. Lempp,Matteo Samuele Pizzuto,John D. Chodera,Christy M. Hebner,Herbert W. Virgin,Herbert W. Virgin,Sean P. J. Whelan,David Veesler,Davide Corti,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom,Gyorgy Snell +61 more
TL;DR: In this paper, the authors comprehensively characterize escape, breadth and potency across a panel of SARS-CoV-2 antibodies targeting the receptor-binding domain (RBD).
Journal ArticleDOI
Broad sarbecovirus neutralization by a human monoclonal antibody.
M. Alejandra Tortorici,M. Alejandra Tortorici,Nadine Czudnochowski,Tyler N. Starr,Roberta Marzi,Alexandra C. Walls,Fabrizia Zatta,John E. Bowen,Stefano Jaconi,Julia di Iulio,Z. Wang,Anna De Marco,Samantha K Zepeda,Dora Pinto,Zhuoming Liu,Martina Beltramello,Istvan Bartha,Michael P. Housley,Florian A. Lempp,Laura E. Rosen,Exequiel Dellota,Hannah Kaiser,Martin Montiel-Ruiz,Jiayi Zhou,Amin Addetia,Barbara Guarino,Katja Culap,Nicole Sprugasci,Christian Saliba,Eneida Vetti,Isabella Giacchetto-Sasselli,Chiara Silacci Fregni,Rana Abdelnabi,Shi Yan Caroline Foo,Colin Havenar-Daughton,Michael A. Schmid,Fabio Benigni,Elisabetta Cameroni,Johan Neyts,Amalio Telenti,Herbert W. Virgin,Sean P. J. Whelan,Gyorgy Snell,Jesse D. Bloom,Jesse D. Bloom,Davide Corti,David Veesler,Matteo Samuele Pizzuto +47 more
TL;DR: S2X259 as discussed by the authors is a human monoclonal antibody that recognizes a highly conserved cryptic epitope of the receptor-binding domain and cross-reacts with spikes from all clades of sarbecovirus.
Posted ContentDOI
Neutralizing antibodies correlate with protection from SARS-CoV-2 in humans during a fishery vessel outbreak with high attack rate
Amin Addetia,Katharine H.D. Crawford,Adam S. Dingens,Haiying Zhu,Pavitra Roychoudhury,Meei-Li Huang,Keith R. Jerome,Jesse D. Bloom,Alexander L. Greninger +8 more
TL;DR: The development of vaccines against SARS-CoV-2 would be greatly facilitated by the identification of immunological correlates of protection in humans, and the presence of neutralizing antibodies from prior infection was significantly associated with protection against re-infection.