Michelle M. Stein

TL;DR: The results of these studies in humans and mice indicate that the Amish environment provides protection against asthma by engaging and shaping the innate immune response.

TL;DR: Variants at the 17q21 locus were associated with asthma in children who had had HRV wheezing illnesses and with expression of two genes at this locus.

TL;DR: The inconsistent association between asthma and gene expression levels in blood or lung cells from older children and adults suggests that genotype effects may mediate asthma risk or protection during critical developmental windows and/or in response to relevant exposures in early life.

TL;DR: In this paper, a pan-cancer TO platform with chemically defined media optimized on cultures acquired from over 1,000 patients was presented, and a neural-network-based high-throughput approach for label-free, light-microscopy-based drug assays capable of predicting patient-specific heterogeneity in drug responses was demonstrated.

TL;DR: Amish children's blood leukocytes are not only altered in their innate immune status, but additionally have distinct T cell phenotypes that are often associated with increased antigenic exposure.