The role of interleukin-6 signaling in nervous tissue.
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TLDR
A modified, recombinant dimerized version of sgp130 (sgp130Fc) has successfully been used to block inflammatory processes in mice and may also be used in the clarification of IL-6 trans-signaling in neurological diseases.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2016-06-01 and is currently open access. It has received 313 citations till now. The article focuses on the topics: Neurotrophic factors & Neurodegeneration.read more
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Inflammation as a central mechanism in Alzheimer's disease
Jefferson W. Kinney,Shane M. Bemiller,Andrew S. Murtishaw,Amanda M. Leisgang,Arnold Salazar,Bruce T. Lamb +5 more
TL;DR: An overview of inflammation in AD is provided and a detailed coverage of a number of microglia‐related signaling mechanisms that have been implicated in AD are reviewed.
Journal ArticleDOI
Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update.
Hua Su,Chun-Tao Lei,Chun Zhang +2 more
TL;DR: An overview of basic concept of IL- 6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells are provided.
Journal ArticleDOI
Post-stroke inflammation-target or tool for therapy?
TL;DR: The cell biology of the post-stroke inflammatory response is summarized and pharmacological interventions targeting inflammation in the acute phase after a stroke that may be used alone or in combination with recanalization therapies are discussed.
Journal ArticleDOI
Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner
Emily F. Willis,Kelli P. A. MacDonald,Quan Nguyen,Adahir Labrador Garrido,Ellen R. Gillespie,Samuel B. R. Harley,Perry F. Bartlett,Wayne A. Schroder,Wayne A. Schroder,Abi G. Yates,Daniel C. Anthony,Stefan Rose-John,Marc J. Ruitenberg,Jana Vukovic +13 more
TL;DR: It is concluded that microglia in the mammalian brain can be manipulated to adopt a neuroprotective and pro-regenerative phenotype that can aid repair and alleviate the cognitive deficits arising from brain injury.
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What does plasma CRP tell us about peripheral and central inflammation in depression
Jennifer C. Felger,Ebrahim Haroon,Trusharth Patel,David R. Goldsmith,Evanthia C. Wommack,Bobbi J. Woolwine,Ngoc-Anh Le,Rachel Feinberg,Malú G. Tansey,Andrew H. Miller +9 more
TL;DR: CRP appears to be a peripheral biomarker that reflects peripheral and central inflammation and seems well-suited for guiding immunotherapies targeting TNF and IL-6 in patients with MDD.
References
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Rating neurologic impairment in multiple sclerosis An expanded disability status scale (EDSS)
TL;DR: A new Expanded Disability Status Scale (EDSS) is presented, with each of the former steps (1,2,3 … 9) now divided into two (1.0, 1.5, 2.0 … 9).
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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Estelle Bettelli,Yijun Carrier,Wenda Gao,Thomas Korn,Terry B. Strom,Mohamed Oukka,Howard L. Weiner,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6, an acute phase protein induced during inflammation, completely inhibits the generation of Foxp3+ Treg cells induced by TGF-β, and the data demonstrate a dichotomy in thegeneration of pathogenic (TH17) T cells that induce autoimmunity and regulatory (Foxp3+) T Cells that inhibit autoimmune tissue injury.
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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
Inge Grundke-Iqbal,Khalid Iqbal,Yunn-Chyn Tung,Maureen Quinlan,Henryk M. Wisniewski,Lester I. Binder +5 more
TL;DR: It is suggested that tau in Alzheimer brain is an abnormally phosphorylated protein component of PHF, the two major locations of paired-helical filaments in Alzheimer disease brain.
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Principles of interleukin (IL)-6-type cytokine signalling and its regulation.
Peter C. Heinrich,Iris Behrmann,Serge Haan,Heike M. Hermanns,Gerhard Müller-Newen,Fred Schaper +5 more
TL;DR: This review focuses on recent progress in the understanding of the molecular mechanisms of IL-6-type cytokine signal transduction, with emphasis on the termination and modulation of the JAK/STAT signalling pathway mediated by tyrosine phosphatases, the SOCS (suppressor of cytokine signalling) feedback inhibitors and PIAS (protein inhibitor of activated STAT) proteins.
Journal ArticleDOI
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
Toshio Hirano,Kiyoshi Yasukawa,Hisashi Harada,Tetsuya Taga,Yasuo Watanabe,Tadashi Matsuda,Shin-ichiro Kashiwamura,Koichi Nakajima,Koichi Koyama,Akihiro Iwamatsu,Susumu Tsunasawa,Fumio Sakiyama,Hiroshi Matsui,Yoshiyuki Takahara,Tadatsugu Taniguchi,Tadamitsu Kishimoto +15 more
TL;DR: The molecular cloning, structural analysis and functional expression of the cDNA encoding human B SF-2 indicated that BSF-2 is functionally and structurally unlike other known proteins.
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