M
Miguel A. Perez-Pinzon
Researcher at University of Miami
Publications - 197
Citations - 8957
Miguel A. Perez-Pinzon is an academic researcher from University of Miami. The author has contributed to research in topics: Ischemia & Ischemic preconditioning. The author has an hindex of 52, co-authored 178 publications receiving 8189 citations. Previous affiliations of Miguel A. Perez-Pinzon include Stanford University & Uppsala University.
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Journal ArticleDOI
Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway.
David Della-Morte,Kunjan R. Dave,Richard A. DeFazio,Y. C. Bao,Ami P. Raval,Miguel A. Perez-Pinzon +5 more
TL;DR: In vivo resveratrol pretreatment confers neuroprotection similar to IPC via the SIRT1-UCP2 pathway, and significantly increased the ADP/O ratio in hippocampal mitochondria reflecting enhanced ATP synthesis efficiency.
Journal ArticleDOI
Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery.
Derek J. Hausenloy,José A. Barrabés,Hans Erik Bøtker,Sean M. Davidson,Fabio Di Lisa,James M. Downey,Thomas Engstrøm,Péter Ferdinandy,Hector A. Carbrera-Fuentes,Gerd Heusch,Borja Ibanez,Efstathios K. Iliodromitis,Javier Inserte,Robert B. Jennings,Neena Kalia,Rajesh K. Kharbanda,Sandrine Lecour,Michael S. Marber,Tetsuji Miura,Michel Ovize,Miguel A. Perez-Pinzon,Hans Michael Piper,Karin Przyklenk,Michael Schmidt,Andrew N. Redington,Marisol Ruiz-Meana,Gemma Vilahur,Jakob Vinten-Johansen,Derek M. Yellon,David Garcia-Dorado +29 more
TL;DR: An overview of the major topics discussed at this special meeting of leading pioneers in the field of cardioprotection to review and discuss the history of IPC, its evolution to IPost and RIC, myocardial reperfusion injury as a therapeutic target, and future targets and strategies for cardioprotsection is provided.
Journal ArticleDOI
Resveratrol Mimics Ischemic Preconditioning in the Brain
TL;DR: It is reported that resveratrol pretreatment mimics IPC via the SIRT1 pathway, and may provide a novel therapy against stroke or neurosurgical procedures.
Journal ArticleDOI
Rapid preconditioning protects rats against ischemic neuronal damage after 3 but not 7 days of reperfusion following global cerebral ischemia
TL;DR: It is demonstrated that neuroprotection against acute neuronal injury can be achieved by conditioning insults followed by only short (30 min) periods of reperfusion, and subsequent rescue of neuronal populations could be achieved with better understanding of the neuroprotective mechanisms involved in this rapid IPC model.
Journal ArticleDOI
εPKC Is Required for the Induction of Tolerance by Ischemic and NMDA-Mediated Preconditioning in the Organotypic Hippocampal Slice
TL;DR: It is corroborated here that IPC and a sublethal dose of NMDA were neuroprotective, whereas blockade ofNMDA receptors during IPC diminished IPC-induced neuroprotection, and it was demonstrated that the εPKC isozyme played a key role in both I PC- and NMDA-induced tolerance.