M
Miguel A. Ramirez
Researcher at Northwestern University
Publications - 3
Citations - 69
Miguel A. Ramirez is an academic researcher from Northwestern University. The author has contributed to research in topics: Noise-induced hearing loss & Proteomics. The author has an hindex of 2, co-authored 3 publications receiving 41 citations.
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Journal ArticleDOI
Global Analysis of Protein Expression of Inner Ear Hair Cells.
Ann E. Hickox,Ann Chi Yan Wong,Ann Chi Yan Wong,Kwang Pak,Chelsee Strojny,Miguel A. Ramirez,John R. Yates,Allen F. Ryan,Jeffrey N. Savas +8 more
TL;DR: Comparison of the proteomic data with mouse and human databases of genetic auditory/vestibular impairments confirms the critical role of the HC proteome for normal IE function, providing a cell-specific pool of candidates for novel, important HC genes.
Journal ArticleDOI
Noise Exposures Causing Hearing Loss Generate Proteotoxic Stress and Activate the Proteostasis Network
Nopporn Jongkamonwiwat,Miguel A. Ramirez,Seby L. Edassery,Ann Chi Yan Wong,Ann Chi Yan Wong,Jintao Yu,Tirzah Abbott,Kwang Pak,Allen F. Ryan,Jeffrey N. Savas +9 more
TL;DR: It is reported that overstimulation of the auditory system drives a robust cochlear proteotoxic stress response, and after two weeks of recovery, the cochlea selectively elevates the abundance of the protein synthesis machinery.
Posted ContentDOI
Altered protein quality control contributes to noise-induced hearing loss
TL;DR: Findings provide a new understanding of noise sensitive proteins and may inform the development of effective preventiative strategies or therapies for NIHL, and shows that noise insults drive a robust proteostasis response.