Noise Exposures Causing Hearing Loss Generate Proteotoxic Stress and Activate the Proteostasis Network
Nopporn Jongkamonwiwat,Miguel A. Ramirez,Seby L. Edassery,Ann Chi Yan Wong,Ann Chi Yan Wong,Jintao Yu,Tirzah Abbott,Kwang Pak,Allen F. Ryan,Jeffrey N. Savas +9 more
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TLDR
It is reported that overstimulation of the auditory system drives a robust cochlear proteotoxic stress response, and after two weeks of recovery, the cochlea selectively elevates the abundance of the protein synthesis machinery.About:
This article is published in Cell Reports.The article was published on 2020-11-24 and is currently open access. It has received 28 citations till now. The article focuses on the topics: Proteostasis & Proteotoxicity.read more
Citations
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A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma.
Beatrice Milon,Eldad David Shulman,Kathy S. So,Christopher R. Cederroth,Erika L. Lipford,Michal Sperber,Jonathan B. Sellon,Heela Sarlus,Gabriela Pregernig,Benjamin Shuster,Yang Song,Sunayana Mitra,Joshua Orvis,Zachary Margulies,Yoko Ogawa,Christopher Shults,Didier A. Depireux,Adam T. Palermo,Barbara Canlon,Joseph C. Burns,Ran Elkon,Ronna Hertzano +21 more
TL;DR: In this article, the authors used RiboTag and single-cell RNA sequencing to survey the cell-type-specific molecular landscape of the mouse inner ear before and after noise trauma and identify induction of the transcription factors STAT3 and IRF7 and immune-related genes across all cell types.
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Molecular and cytological profiling of biological aging of mouse cochlear inner and outer hair cells
Huizhan Liu,Kimberlee P. Giffen,Lei Chen,Heidi J Henderson,Talia Cao,Grant A. Kozeny,Kirk W. Beisel,Yi Li,David Z.Z. He +8 more
TL;DR: Using RNA-seq transcriptomic analyses of inner and outer cochlear hair cells (HCs) isolated from young and aged mice, this paper showed that HC aging is associated with changes in key molecular processes, including transcription, DNA damage, autophagy, and oxidative stress, as well as genes related to HC specialization.
Journal ArticleDOI
Localized Proteasomal Degradation: From the Nucleus to Cell Periphery
TL;DR: Recent advances on the functions, regulations and targeting mechanisms of proteasomes, especially those localized to the nuclear condensates and membrane structures of the cell are summarized and the biological significance thereof in mediating compartmentalized protein degradation is discussed.
Journal ArticleDOI
The amino acid substitution affects cellular response to mistranslation.
Matthew D. Berg,Matthew D. Berg,Yanrui Zhu,Bianca Y Ruiz,Raphaël Loll-Krippleber,Joshua Isaacson,Bryan-Joseph San Luis,Julie Genereaux,Charles Boone,Judit Villén,Grant W. Brown,Christopher J. Brandl +11 more
TL;DR: It is predicted that the potential of mistranslation to exacerbate diseases caused by proteotoxic stress depends on the tRNA variant, and different naturally occurring mistranslating tRNAs have the potential to negatively influence specific diseases.
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Determining and interpreting protein lifetimes in mammalian tissues.
TL;DR: In this article , the authors summarized leading technical approaches and highlighted their strengths and weaknesses. And they also disambiguate frequently used terminology, illustrate recent mechanistic insights, and provide guidance for interpreting and validating protein turnover measurements.
References
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