E
Edda Tobiasch
Researcher at Bonn-Rhein-Sieg University of Applied Sciences
Publications - 67
Citations - 3844
Edda Tobiasch is an academic researcher from Bonn-Rhein-Sieg University of Applied Sciences. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 26, co-authored 65 publications receiving 3485 citations. Previous affiliations of Edda Tobiasch include Beth Israel Deaconess Medical Center & Heidelberg University.
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Journal ArticleDOI
Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis.
Sophie Brouard,Leo E. Otterbein,Josef Anrather,Edda Tobiasch,Fritz H. Bach,Augustine M.K. Choi,Miguel P. Soares +6 more
TL;DR: The data demonstrate that the antiapoptotic effect of HO-1 in ECs is mediated by CO and more specifically via the activation of p38 MAPK by CO.
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Heme Oxygenase-1-derived Carbon Monoxide Requires the Activation of Transcription Factor NF-κB to Protect Endothelial Cells from Tumor Necrosis Factor-α-mediated Apoptosis
Sophie Brouard,Pascal O. Berberat,Edda Tobiasch,Mark P. Seldon,Fritz H. Bach,Miguel P. Soares,Miguel P. Soares +6 more
TL;DR: It is demonstrated that HO-1/CO cooperates with NF-κB-dependent anti-apoptotic genes, i.e. c-IAP2 and A1, to protect EC from TNF-α-mediated apoptosis, which is dependent on the ability of HO- 1/CO to activate the p38 MAPK signal transduction pathway.
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Heavy chain ferritin acts as an antiapoptotic gene that protects livers from ischemia reperfusion injury
Pascal O. Berberat,Masamichi Katori,Elzbieta Kaczmarek,Dean M. Anselmo,Charles Lassman,Bibo Ke,Xiu-Da Shen,Ronald W. Busuttil,Kenichiro Yamashita,Eva Csizmadia,Shivraj Tyagi,Leo E. Otterbein,Sophie Brouard,Edda Tobiasch,Fritz H. Bach,Jerzy W. Kupiec-Weglinski,Miguel P. Soares,Miguel P. Soares +17 more
TL;DR: It is suggested that H‐ferritin can be used in a therapeutic manner to prevent liver IRI and thus maximize the organ donor pool used for transplantation.
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DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation.
TL;DR: Neither phosphorylations of individual amino acids nor interactions of the carboxyterminus of p53 with cellular macromolecules appear to play a role in the stabilization process, and the only single prerequisite for induced stabilization of p 53 is its prior destabilization by Mdm2.
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Mechanisms Underlying the Osteo- and Adipo-Differentiation of Human Mesenchymal Stem Cells
TL;DR: The current findings for adipo- and osteo-differentiation are summarized together with a brief statement on first clinical trials.