Mihail S. Iordanov

TL;DR: It is found that aminohexose pyrimidine nucleoside antibiotics, which bind to the same region in the 28S rRNA that is the target site for anisomycin, are also potent activators of SAPK/JNK1.

TL;DR: It is shown that Th17 cytokines stimulate CCL20 production in vitro and in vivo, and thus provide a potential explanation of how CCR6-positive Th17 cells maintain their continual presence in psoriasis through a positive chemotactic feedback loop.

TL;DR: UV is absorbed by several target molecules relevant for cellular signaling, and it appears that numerous signal transduction pathways are stimulated.

TL;DR: It is found that UVC‐induced transcriptional activation depends also on the CRE at position −60 of the c‐fos promoter and on the functionality of a CREB, which represents an as yet unrecognized route of U VC‐induced signal transduction, independent of suramin‐inhibitable growth factor receptors and different from the Erk 1,2–p62TCF pathway.

TL;DR: A novel form of dsRNA-triggered signaling that leads to the stimulation of the p38 mitogen-activated protein kinase (p38 MAPK) and the c-Jun NH2-terminal Kinase (JNK) and of their respective activators MKK3/6 and SEK1/MKK4 is described.