Andrew Blauvelt

TL;DR: Dupilumab improved the signs and symptoms of atopic dermatitis, including pruritus, symptoms of anxiety and depression, and quality of life, as compared with placebo in two phase 3 trials of identical design.

TL;DR: In this paper, the importance of T helper 17 (Th17) cells in inflammation and autoimmunity is recognized, and they localized Th17 cells predominantly to the dermis of psoriasis skin lesions, confirmed that IL-17 mRNA increased with disease activity, and demonstrated that IL 17 mRNA expression normalized with cyclosporine therapy.

TL;DR: This 1-year, randomised, double-blinded, placebo-controlled, phase 3 study aimed to evaluate the long-term efficacy and safety of dupilumab with medium-potency topical corticosteroids versus placebo with topical cortiosteroids in adults with moderate-to-severe atopic dermatitis.

TL;DR: Data demonstrate that human skin dendritic cells are permissive for DV infection, and provide a potential mechanism for the transmission of DV into human skin.

TL;DR: In this article, the authors used a mouse model of S. aureus cutaneous infection to investigate the contribution of T cells to host defense, and they found that mice deficient in γδ but not αβ T cells had substantially larger skin lesions with higher bacterial counts and impaired neutrophil recruitment compared with WT mice.