H
Hans J. Rahmsdorf
Researcher at Karlsruhe Institute of Technology
Publications - 53
Citations - 10381
Hans J. Rahmsdorf is an academic researcher from Karlsruhe Institute of Technology. The author has contributed to research in topics: Transcription factor & Gene expression. The author has an hindex of 32, co-authored 53 publications receiving 10303 citations.
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Journal ArticleDOI
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.
Peter Angel,Masayoshi Imagawa,Robert Chiu,Bernd Stein,Richard J. Imbra,Hans J. Rahmsdorf,Carsten Jonat,Peter Herrlich,Michael Karin +8 more
TL;DR: Results strongly suggest that AP-1 is at the receiving end of a complex pathway responsible for transmitting the effects of phorbol ester tumor promoters from the plasma membrane to the transcriptional machinery.
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Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
Carsten Jonat,Hans J. Rahmsdorf,Kun-Koo Park,Andrew C.B. Cato,Stephan Gebel,Helmut Ponta,Peter Herrlich +6 more
TL;DR: Coprecipitation experiments suggest direct AP-1-hormone receptor interaction, which also possibly explains the reverse experiment: overexpression of Fos or Jun inhibits the expression of hormone-dependent genes.
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12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.
TL;DR: Differences in enhancer efficiency in different cell lines are interpreted to indicate differences in the activity of a trans-acting factor.
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Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters.
TL;DR: These results establish a key role for fos in signal transduction and implicate the fos protein as a trans-activating and -repressing molecule.
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UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.
TL;DR: The primary target of relevant UV absorption, on pathways leading to gene activation, and on the elements receiving the UV-induced signal in the human immunodeficiency virus type 1 (HIV-1) long terminal repeat, in the gene coding for collagenase, and in the cellular oncogene fos are reported on.