M
Miikka-Juhani Honka
Researcher at University of Turku
Publications - 29
Citations - 834
Miikka-Juhani Honka is an academic researcher from University of Turku. The author has contributed to research in topics: Insulin resistance & Glucose uptake. The author has an hindex of 13, co-authored 24 publications receiving 597 citations. Previous affiliations of Miikka-Juhani Honka include Turku University Hospital.
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Journal ArticleDOI
Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids
Matej Orešič,Tuulia Hyötyläinen,Anna Kotronen,Peddinti Gopalacharyulu,Heli Nygren,Johanna Arola,Sandra Castillo,Ismo Mattila,Antti Hakkarainen,Ronald Borra,Ronald Borra,Miikka-Juhani Honka,An Verrijken,Sven Francque,Patricia Iozzo,Patricia Iozzo,Marja Leivonen,Nabil Jaser,Anne Juuti,Thorkild I. A. Sørensen,Pirjo Nuutila,Luc Van Gaal,Hannele Yki-Järvinen +22 more
TL;DR: The liver-fat-biomarker signature based on molecular lipids may provide a non-invasive tool to diagnose NAFLD, in addition to highlighting lipid molecular pathways involved in the disease.
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The SGLT2 Inhibitor Dapagliflozin Reduces Liver Fat but Does Not Affect Tissue Insulin Sensitivity: A Randomized, Double-Blind, Placebo-Controlled Study With 8-Week Treatment in Type 2 Diabetes Patients
Aino Latva-Rasku,Miikka-Juhani Honka,Joel Kullberg,Nina Mononen,Terho Lehtimäki,Juha Saltevo,Anna K. Kirjavainen,Virva Saunavaara,Patricia Iozzo,Lars Johansson,Jan Oscarsson,Jarna C. Hannukainen,Pirjo Nuutila,Pirjo Nuutila +13 more
TL;DR: 8 weeks of treatment with dapagliflozin reduced liver PDFF and the volume of visceral adipose tissue in obese patients with type 2 diabetes and, although glycemic control was improved, no effect on tissue-level insulin sensitivity was observed.
Journal ArticleDOI
Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance
Jussi Hirvonen,Kirsi A. Virtanen,Lauri Nummenmaa,Jarna C. Hannukainen,Miikka-Juhani Honka,Marco Bucci,Sergey V. Nesterov,Riitta Parkkola,Juha O. Rinne,Patricia Iozzo,Pirjo Nuutila +10 more
TL;DR: It is found that insulin stimulates brain glucose metabolism at physiological postprandial levels in patients with impaired glucose tolerance but not in healthy subjects, and this effect of insulin is already maximal at fasting concentrations inhealthy subjects.
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Insulin-stimulated glucose uptake in skeletal muscle, adipose tissue and liver: a positron emission tomography study.
Miikka-Juhani Honka,Aino Latva-Rasku,Marco Bucci,Kirsi A. Virtanen,Jarna C. Hannukainen,Kari K. Kalliokoski,Pirjo Nuutila +6 more
TL;DR: In this article, the rates of reduced glucose uptake (GU) into the key insulin-sensitive tissues, skeletal muscle, liver and adipose tissue, were measured in a single session using positron emission tomography (PET) and euglycemic-hyperinsulinemic clamp.
Journal ArticleDOI
Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity.
Jenni Hyysalo,Peddinti Gopalacharyulu,Hua Bian,Tuulia Hyötyläinen,Marja Leivonen,Nabil Jaser,Anne Juuti,Miikka-Juhani Honka,Pirjo Nuutila,Vesa M. Olkkonen,Matej Orešič,Hannele Yki-Järvinen,Hannele Yki-Järvinen +12 more
TL;DR: ‘PNPLA3 NAFLD’ is associated with a relative deficiency of TAGs, supporting the idea that the I148M variant impedes intrahepatocellular lipolysis rather than stimulates TAG synthesis, which can be attributed to obesity/insulin resistance rather than increased liver fat content per se.