Soheila Najafzadeh

TL;DR: It is suggested that abnormal CB1 receptor-mediated anandamide signaling is implicated in the etiology of PTSD, and provide a promising neurobiological model to develop novel, evidence-based pharmacotherapies for this disorder.

TL;DR: This approach may provide a direct measure of synaptic density, and it therefore holds promise as an in vivo biomarker for AD and as an outcome measure for trials of disease-modifying therapies, particularly those targeted at the preservation and restoration of synapses.

TL;DR: Whole-body biodistribution revealed that the liver and the brain are the dose-limiting organs for males and females, respectively, and 11C-UCB-J exhibited excellent characteristics as an SV2A PET radiotracer in nonhuman primates.

TL;DR: The reductions found in this study suggest that 5-HT1B receptors may contribute to the etiology or expression of CD and potentially represent a target for medication development.

TL;DR: The results suggest that quantification of 11C-LY2795050 imaging is reproducible and reliable in regions with moderate and high KOR density and therefore this first antagonist radiotracer is highly useful for PET studies of KOR.