Mildred Pochet

TL;DR: It is suggested that JAM plays an important role in the regulation of tight junction assembly in epithelia, and these JAM-mediated effects may occur by either direct, or indirect interactions with occludin.

TL;DR: It is shown that anti-CD47 monoclonal antibodies delay PMN migration across collagen-coated filters or T84 epithelial monolayers toward the chemoattractant formylmethionylleucylphenylalanine (fMLP).

TL;DR: A monoclonal antibody called g82 was produced that inhibited PMN transepithelial migration in the physiological basolateral-to-apical direction and identified a new mechanism for retention of PMN at the apical epithelial surface following transe Pithelial migration.

TL;DR: Survey of FAS in cell lines established from normal murine mammary epithelium and from mammary tumors induced by either rodent polyoma (Py) virus or murine Mammary tumor virus revealed greater content of F AS in Py-transformed A1-1 and T1 than NMuMG or MMTV- transformed Mm5MT, RIIIMT and MMT060562, suggesting that signaling events mediated by Py transformation may increase cellular amounts of Fas.

TL;DR: The antineoplastic properties of cerulenin documented here are consistent with prior studies showing its cytotoxic effects upon other types of cancer cells and illustrate the potential utility of FAS inhibition as a novel chemotherapeutic approach.