Frederick J. Schnell

TL;DR: Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.

TL;DR: It is suggested that JAM plays an important role in the regulation of tight junction assembly in epithelia, and these JAM-mediated effects may occur by either direct, or indirect interactions with occludin.

TL;DR: It is shown that SirPα1 directly binds to the immunoglobulin variable domain loop of purified human CD47 and that such SIRP-CD47 interactions regulate PMN transmigration, demonstrating that PMN migration is regulated by CD47 through SIRpα-dependent and SIRFα-independent mechanisms.

TL;DR: Results confirm that culture of human umbilical vein endothelial cells with TNF-alpha plus IFN-gamma caused a decrease in surface-expressed and junctional-localized JAM and PECAM-1, but did not cause decreased leukocyte transmigration in an in vitro flow assay, suggesting lack of correlation between transmigration and loss of permeability.

TL;DR: It is concluded that IL-7 is a pivotal upstream target through which estrogen regulates hematopoietic and immune functions that are critical for bone homeostasis and due to both the thymic and extrathymic mechanisms.