Titus A. Reaves

TL;DR: It is suggested that JAM plays an important role in the regulation of tight junction assembly in epithelia, and these JAM-mediated effects may occur by either direct, or indirect interactions with occludin.

TL;DR: This study modeled PMN transepithelial migration across T84 monolayers and demonstrated that enhanced paracellular permeability to small solutes occurred in the absence of transe pithelial migration but required both PMN contact with the epithelial cell basolateral membrane and a transe Pithelial chemotactic gradient.

TL;DR: Tranansepithelial migration requires sequential adhesive interactions between the PMN beta2 integrin CD11b/CD18 and JAM protein family members, and Toll-like receptors (TLR) are differentially expressed on both leukocytes and mucosal epithelial cells while serving to modulate leukocyte-epithelial interactions.

TL;DR: Activation of CD47 signaling enhances PMN sensitivity toward TLR2 activation which, in turn, signals their arrival at a site of invasion and may facilitate antimicrobial function.

TL;DR: A monoclonal antibody called g82 was produced that inhibited PMN transepithelial migration in the physiological basolateral-to-apical direction and identified a new mechanism for retention of PMN at the apical epithelial surface following transe Pithelial migration.