M
Milena Hristova
Researcher at University of Vermont
Publications - 14
Citations - 2327
Milena Hristova is an academic researcher from University of Vermont. The author has contributed to research in topics: Inflammation & Allergic inflammation. The author has an hindex of 10, co-authored 13 publications receiving 2219 citations. Previous affiliations of Milena Hristova include University of California, Davis.
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Journal ArticleDOI
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
Jason P. Eiserich,Jason P. Eiserich,Milena Hristova,Carroll E. Cross,A. Daniel Jones,Bruce A. Freeman,Barry Halliwell,Barry Halliwell,Albert van der Vliet +8 more
TL;DR: The data reveal that NO2− may regulate inflammatory processes through oxidative mechanisms, perhaps by contributing to the tyrosine nitration and chlorination observed in vivo.
Journal ArticleDOI
Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta.
Niki L. Reynaert,Albert van der Vliet,Amy S. Guala,Toby K. McGovern,Milena Hristova,Cristen Pantano,Nicholas H. Heintz,John Heim,Ye-Shih Ho,Dwight E. Matthews,Emiel F.M. Wouters,Yvonne M. W. Janssen-Heininger +11 more
TL;DR: The physiological relevance of the S-glutathionylation–GRX redox module in controlling the magnitude of activation of the NF-κB pathway is demonstrated.
Journal ArticleDOI
Peroxynitrite induces covalent dimerization of epidermal growth factor receptors in A431 epidermoid carcinoma cells
TL;DR: Exposure of A431 cells to ONOO− markedly reduced the kinetics of tyrosine phosphorylation of a downstream EGFR substrate, phospholipase C-γ1, which may be related to covalent alterations in EGFR.
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Nitric oxide promotes airway epithelial wound repair through enhanced activation of MMP-9.
Peter F. Bove,Umadevi V. Wesley,Anne-Katrin Greul,Milena Hristova,Wolfgang R. Dostmann,Albert van der Vliet +5 more
TL;DR: It is demonstrated that NOS2-derived NO contributes to airway epithelial repair by both PKG-dependent and -independent mechanisms, and involves NO-dependent expression and activation of MMP-9.
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Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction
TL;DR: It is suggested that loss of epithelial barrier integrity by oxidative stress is minimized by activation of HIF-1, in part by induction of sestrin-2, a hypoxia-inducible enzyme known to reduce oxidative stress and minimize Prx hyperoxidation.