M
Min-Han Tan
Researcher at Agency for Science, Technology and Research
Publications - 186
Citations - 10277
Min-Han Tan is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Cancer & Renal cell carcinoma. The author has an hindex of 40, co-authored 173 publications receiving 8967 citations. Previous affiliations of Min-Han Tan include Singapore General Hospital & National Center for Charitable Statistics.
Papers
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MassMark: A Highly Scalable Multiplex NGS-based Method for High-Throughput, Accurate and Sensitive Detection of SARS-CoV-2 for Mass Testing
TL;DR: In this article, a scalable multiplex method that employs next generation sequencing for high-throughput, accurate and sensitive detection of SARS-CoV-2, while minimizing handling complexity and resources by utilizing a serial pooling strategy to accommodate over 9,000 samples per workflow.
Journal ArticleDOI
Abstract A22: Complete mutation concordance with amplicon-based NGS between peripheral blood and bone marrow at 0.5% VAF threshold
TL;DR: Lim et al. as mentioned in this paper demonstrate the relationship of NGS signals between PB and BM, and show that PB NGS is particularly sensitive for detection of myeloid specific mutations in de novo and secondary AMLs with complete concordance at VAFs ≥ 0.5.
Journal ArticleDOI
A comprehensive next generation sequencing tissue assay for Asian-prevalent cancers—Analytical validation and performance evaluation with clinical samples
Cedric Chuan Young Ng,Sandy H H Lim,Abner Herbert Lim,Nur Diyana Md Nasir,Jinxia Zhang,Vikneswari Rajasegaran,Jing Yi Lee,Jessica Sook Ting Kok,Aye Aye Thike,Johnathan Xiande Lim,Ruifen Weng,Sidney Yee,Yukti Choudhury,Jason Yongsheng Chan,Puay Hoon Tan,Min-Han Tan,Bin Tean Teh +16 more
TL;DR: The results demonstrate a molecular diagnostic assay that accurately detects genomic alterations and complex biomarkers that complements clinicopathological factors to facilitate early diagnosis and ensure timely treatment delivery in Asian prevalent cancers.
Patent
Single cell rna and mutational analysis pcr (scrm-pcr): a method for simultaneous analysis of dna and rna at the single-cell level
Min-Han Tan,Igor Cima +1 more
TL;DR: In this article, a method of simultaneously analyzing RNA and DNA in a sample is proposed, which involves contacting the sample with a reverse primer from a first primer pair directed to a target RNA region to effect reverse transcription of RNA into cDNA with reverse transcriptase.
Patent
Method for predicting clinical toxicity and outcome
TL;DR: In this paper, a method for determining the sensitivity of a patient with cancer to receptor tyrosine kinase inhibitor therapy is provided, where the sensitivity is selected from one or more of neutropenia, diarrhea, tumor response, early toxicity-necessitated treatment termination, overall survival and progression-free survival.