C
Cedric Chuan Young Ng
Researcher at National University of Singapore
Publications - 61
Citations - 3686
Cedric Chuan Young Ng is an academic researcher from National University of Singapore. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 17, co-authored 42 publications receiving 2764 citations. Previous affiliations of Cedric Chuan Young Ng include Agency for Science, Technology and Research.
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Journal ArticleDOI
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
Zhi Jiang Zang,Ioana Cutcutache,Song Ling Poon,Shen Li Zhang,John R. McPherson,Jiong Tao,Vikneswari Rajasegaran,Hong Lee Heng,Niantao Deng,Anna Gan,Kiat Hon Lim,Choon Kiat Ong,Dachuan Huang,Sze Yung Chin,Iain Beehuat Tan,Cedric Chuan Young Ng,Willie Yu,Yingting Wu,Minghui Lee,Jeanie Wu,Dianne Poh,Wei Keat Wan,Sun Young Rha,Jimmy Bok Yan So,Manuel Salto-Tellez,Manuel Salto-Tellez,Khay Guan Yeoh,Wai-Keong Wong,Yi Jun Zhu,P. Andrew Futreal,Brendan Pang,Yijun Ruan,Axel M. Hillmer,Denis Bertrand,Niranjan Nagarajan,Steve Rozen,Bin Tean Teh,Bin Tean Teh,Patrick Tan,Patrick Tan +39 more
TL;DR: Somatic inactivation of FAT4 and ARID1A may be key tumorigenic events in a subset of gastric cancers, and cell adhesion was the most enriched biological pathway among the frequently mutated genes.
Journal ArticleDOI
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
Apinya Jusakul,Apinya Jusakul,Ioana Cutcutache,Chern Han Yong,Jing Quan Lim,Mi Ni Huang,Nisha Padmanabhan,Vishwa Nellore,Sarinya Kongpetch,Alvin Wei Tian Ng,Ley Moy Ng,Su Pin Choo,Swe Swe Myint,Raynoo Thanan,Sanjanaa Nagarajan,Weng Khong Lim,Cedric Chuan Young Ng,Arnoud Boot,Mo Liu,Choon Kiat Ong,Vikneswari Rajasegaran,Stefanus Lie,Alvin Soon Tiong Lim,Tse Hui Lim,Jing Tan,Jia Liang Loh,John R. McPherson,Narong Khuntikeo,Vajaraphongsa Bhudhisawasdi,Puangrat Yongvanit,Sopit Wongkham,Yasushi Totoki,Hiromi Nakamura,Yasuhito Arai,Satoshi Yamasaki,Pierce K. H. Chow,Alexander Y. F. Chung,London L.P.J. Ooi,Kiat Hon Lim,Simona Dima,Dan G. Duda,Irinel Popescu,Philippe Broët,Sen-Yung Hsieh,Ming-Chin Yu,Aldo Scarpa,Jiaming Lai,Di-Xian Luo,André Lopes Carvalho,André Luiz Vettore,Hyungjin Rhee,Young Nyun Park,Ludmil B. Alexandrov,Raluca Gordân,Steven G. Rozen,Tatsuhiro Shibata,Chawalit Pairojkul,Bin Tean Teh,Patrick Tan +58 more
TL;DR: In this paper, the authors analyzed 489 cholangiocarcinoma (CCA) from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene expression, and DNA methylation information.
Journal ArticleDOI
Exome sequencing of liver fluke–associated cholangiocarcinoma
Choon Kiat Ong,Chutima Subimerb,Chutima Subimerb,Chawalit Pairojkul,Sopit Wongkham,Ioana Cutcutache,Willie Yu,John R. McPherson,George E. Allen,Cedric Chuan Young Ng,Bernice Huimin Wong,Swe Swe Myint,Vikneswari Rajasegaran,Hong Lee Heng,Anna Gan,Zhi Jiang Zang,Yingting Wu,Yingting Wu,Jeanie Wu,Ming Hui Lee,Dachuan Huang,Pauline Ong,Waraporn Chan-on,Waraporn Chan-on,Yun Cao,Chao Nan Qian,Kiat Hon Lim,Aikseng Ooi,Karl Dykema,Kyle A. Furge,Veerapol Kukongviriyapan,Banchob Sripa,Chaisiri Wongkham,Puangrat Yongvanit,P. Andrew Futreal,Vajarabhongsa Bhudhisawasdi,Steve Rozen,Patrick Tan,Patrick Tan,Bin Tean Teh +39 more
TL;DR: Insight into the mutational landscape contributing to O. viverrini–related CCA is provided and 206 somatic mutations in 187 genes using Sanger sequencing are identified and selected 15 genes for mutation prevalence screening in an additional 46 individuals with CCA.
Journal ArticleDOI
Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers
Waraporn Chan-on,Waraporn Chan-on,Maarja-Liisa Nairismagi,Choon Kiat Ong,Weng Khong Lim,Simona Dima,Chawalit Pairojkul,Kiat Hon Lim,John R. McPherson,Ioana Cutcutache,Hong Lee Heng,London L.P.J. Ooi,Alexander Y. F. Chung,Pierce K. H. Chow,Peng Chung Cheow,Ser Yee Lee,Su Pin Choo,Iain Beehuat Tan,Dan G. Duda,Anca Nastase,Swe Swe Myint,Bernice Huimin Wong,Anna Gan,Vikneswari Rajasegaran,Cedric Chuan Young Ng,Sanjanaa Nagarajan,Apinya Jusakul,Shenli Zhang,Priya Vohra,Willie Yu,Dachuan Huang,Paiboon Sithithaworn,Puangrat Yongvanit,Sopit Wongkham,Narong Khuntikeo,Vajaraphongsa Bhudhisawasdi,Irinel Popescu,Steven G. Rozen,Patrick Tan,Patrick Tan,Bin Tean Teh +40 more
TL;DR: Functional studies demonstrated tumor suppressive functions for BAP1 and ARID1A, establishing the role of chromatin modulators in CCA pathogenesis and indicating that different causative etiologies may induce distinct somatic alterations, even within the same tumor type.
Journal ArticleDOI
Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia
Alvin Wei Tian Ng,Song Ling Poon,Mi Ni Huang,Jing Quan Lim,Arnoud Boot,Willie Yu,Yuka Suzuki,Saranya Thangaraju,Cedric Chuan Young Ng,Patrick Tan,See Tong Pang,Hao Yi Huang,Ming-Chin Yu,Po Huang Lee,Sen Yung Hsieh,Alex Y. Chang,Bin Tean Teh,Steven G. Rozen +17 more
TL;DR: The authors showed that the use of this drug remains widespread in Asia and particularly in Taiwan, and that it appears to increase the risk of multiple different cancer types, and proposed that additional measures aimed at primary prevention through avoidance of AA exposure and investigation of possible approaches to secondary prevention are warranted.