M
Min-Han Tan
Researcher at Agency for Science, Technology and Research
Publications - 186
Citations - 10277
Min-Han Tan is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Cancer & Renal cell carcinoma. The author has an hindex of 40, co-authored 173 publications receiving 8967 citations. Previous affiliations of Min-Han Tan include Singapore General Hospital & National Center for Charitable Statistics.
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Journal ArticleDOI
Parafibromin expression in breast cancer: a novel marker for prognostication?
Sathiyamoorthy Selvarajan,Lang Hiong Sii,Adrian Y.S. Lee,George W. Yip,Boon-Huat Bay,Min-Han Tan,Bin Tean Teh,Puay Hoon Tan +7 more
TL;DR: Parafibromin in breast cancer, as in parathyroid tumours, appears to have tumour suppressor functions, with loss of protein expression associated with adverse pathological parameters, which may indicate a potential role of parafIBromin as a prognostic marker in Breast cancer.
Journal ArticleDOI
Overexpression of glutathione s-transferase alpha in clear cell renal cell carcinoma.
Shang-Tian Chuang,Peiguo Chu,Jun Sugimura,Maria Tretiakova,Veronica Papavero,Kim L. Wang,Min-Han Tan,Fan Lin,Bin Tean Teh,Ximing J. Yang +9 more
TL;DR: GST-alpha was demonstrated as a biomarker for clear cell RCCs through cDNA microarrays and immunohistochemical analysis, demonstrating strong and diffuse GST-alpha immunoreactivity.
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Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity.
Yukti Choudhury,Yi-Chin Toh,Jiangwa Xing,Yinghua Qu,Jonathan Poh,Huan Li,Hui Shan Tan,Ravindran Kanesvaran,Hanry Yu,Hanry Yu,Min-Han Tan +10 more
TL;DR: This study establishes the first patient-specific HLC-based platform for idiosyncratic hepatotoxicity testing, incorporating multiple potential causative factors and permitting the correlation of transcriptomic and cellular responses to clinical phenotypes.
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Overexpression of Glutathione S-Transferase α in Clear Cell Renal Cell Carcinoma
Shang Tian Chuang,Peiguo Chu,Jun Sugimura,Maria Tretiakova,Veronica Papavero,Kim L. Wang,Min-Han Tan,Fan Lin,Bin Tean Teh,Ximing J. Yang +9 more
TL;DR: GST-α was demonstrated as a biomarker for clear cell RCCs through cDNA microarrays and immunohistochemical analysis, demonstrating strong and diffuse GST-α immunoreactivity.
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Phenformin-loaded polymeric micelles for targeting both cancer cells and cancer stem cells in vitro and in vivo
TL;DR: In vivo studies conducted in an H460 human lung cancer mouse model, it was demonstrated that the drug-loaded micelles had greater anti-tumor efficacy, and reduced the population of SP cells in the tumor tissues more effectively than free phenformin.