Min Xue

TL;DR: Recent efforts to develop MSNPs as biocompatible nanocarriers that simultaneously display multiple functions including high visibility/contrast in multiple imaging modalities, dispersibility, binding specificity to a particular target tissue or cell type, ability to load and deliver large concentrations of diverse cargos, and triggered or controlled release of cargo.

TL;DR: A novel MSNP delivery system capable of drug delivery based on the function of beta-cyclodextrin (beta-CD) nanovalves that are responsive to the endosomal acidification conditions in human differentiated myeloid and squamous carcinoma cell lines are reported.

TL;DR: Proof-of-principle testing of the use of a dual drug/siRNA nanocarrier to overcome Dox resistance in a xenograft is provided and the first detailed analysis of the impact of heterogeneity in the tumor microenvironment on the efficacy of siRNA delivery in vivo is provided.

TL;DR: It is demonstrated that size reduction and surface functionalization of mesoporous silica nanoparticles (MSNP) with a polyethyleneimine-polyethylene glycol copolymer reduces particle opsonization while enhancing the passive delivery to a human squamous carcinoma xenograft in nude mice after intravenous injection.

TL;DR: This study emphasizes that not all amorphous silicas are created equal and that the unusual toxicity of fumed silica compared to that of colloidal silica derives from its framework and surface chemistry along with its fused chainlike morphology established by high-temperature synthesis and rapid thermal quenching.